ID   SYR_STRGG               Reviewed;         594 AA.
AC   B1VTB7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Arginine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            EC=6.1.1.19 {ECO:0000255|HAMAP-Rule:MF_00123};
DE   AltName: Full=Arginyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            Short=ArgRS {ECO:0000255|HAMAP-Rule:MF_00123};
GN   Name=argS {ECO:0000255|HAMAP-Rule:MF_00123}; OrderedLocusNames=SGR_4178;
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350;
RX   PubMed=18375553; DOI=10.1128/jb.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism Streptomyces
RT   griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC         tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC         COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC         EC=6.1.1.19; Evidence={ECO:0000255|HAMAP-Rule:MF_00123};
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00123}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00123}.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00123}.
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DR   EMBL; AP009493; BAG21007.1; -; Genomic_DNA.
DR   RefSeq; WP_012380409.1; NC_010572.1.
DR   AlphaFoldDB; B1VTB7; -.
DR   SMR; B1VTB7; -.
DR   STRING; 455632.SGR_4178; -.
DR   EnsemblBacteria; BAG21007; BAG21007; SGR_4178.
DR   GeneID; 6209259; -.
DR   KEGG; sgr:SGR_4178; -.
DR   PATRIC; fig|455632.4.peg.4255; -.
DR   eggNOG; COG0018; Bacteria.
DR   HOGENOM; CLU_006406_5_1_11; -.
DR   OMA; HHIGDWG; -.
DR   OrthoDB; 1146366at2; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006420; P:arginyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR   CDD; cd00671; ArgRS_core; 1.
DR   Gene3D; 3.30.1360.70; -; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_00123; Arg_tRNA_synth; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR001278; Arg-tRNA-ligase.
DR   InterPro; IPR005148; Arg-tRNA-synth_N.
DR   InterPro; IPR036695; Arg-tRNA-synth_N_sf.
DR   InterPro; IPR035684; ArgRS_core.
DR   InterPro; IPR008909; DALR_anticod-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   PANTHER; PTHR11956; PTHR11956; 1.
DR   Pfam; PF03485; Arg_tRNA_synt_N; 1.
DR   Pfam; PF05746; DALR_1; 1.
DR   Pfam; PF00750; tRNA-synt_1d; 1.
DR   PRINTS; PR01038; TRNASYNTHARG.
DR   SMART; SM01016; Arg_tRNA_synt_N; 1.
DR   SMART; SM00836; DALR_1; 1.
DR   SUPFAM; SSF47323; SSF47323; 1.
DR   SUPFAM; SSF55190; SSF55190; 1.
DR   TIGRFAMs; TIGR00456; argS; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis.
FT   CHAIN           1..594
FT                   /note="Arginine--tRNA ligase"
FT                   /id="PRO_1000095408"
FT   MOTIF           127..137
FT                   /note="'HIGH' region"
SQ   SEQUENCE   594 AA;  64757 MW;  D572DB562773B6BA CRC64;
     MASVPSLAST LQQQLADALT AALPDAGAAD PLLRRSDRAD FQANGILALA KKLKGNPREL
     AAQVTAALPA GGLIKDIEVS GPGFLNVTLT DRAIVETLAA RAADGEGRLG VPLKDDAGTT
     VIDYAQPNVA KEMHVGHLRS AVIGDAVVRI LEFTGENVVR RHHIGDWGTQ FGMLIQYLIE
     HPGALQHEGG PGDGASDGEA AMSTLNRVYK ESRALFDSDE EFKARSRDRV VALQAGDPGT
     LELWHRFVDE SKIYFHSVFD KLDMEIRDPD IVGESGYNDM LEETCRILEE TGVAVRSEGA
     LCVFFDDVKG PDGNRVPLIV KKTNGGYGYA ATDLSAVRNR VQDLKADTLL YVVDARQSLH
     FRMVFETARR AGWLGDDVKA VQLAFGTVLG KDGKPFKTRE GETVRLEDLL DEAVQRATAV
     VRDKAEKVGL SEEEIVENGR YVGIGAVKYA DLSTSAVRDY KFDLDQMVAL HGDTSVYLQY
     AYARIRSILR KAGDAVPAAH PELELAPAER ALGLHLDQFG EVLAEVGTGY EPHKLAAYLY
     QLASHLTTFY DQCQVLSPDN APEVVENRLF LVELTARTLH RGMALLGIRT PERL