ID   BNL2A_EBVG              Reviewed;          60 AA.
AC   P0C738; Q04361; Q8AZJ2;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   23-FEB-2022, entry version 35.
DE   RecName: Full=Protein BNLF2a;
GN   ORFNames=BNLF2a;
OS   Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=10376;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16306603; DOI=10.1128/jvi.79.24.15323-15330.2005;
RA   Zeng M.-S., Li D.-J., Liu Q.-L., Song L.-B., Li M.-Z., Zhang R.-H.,
RA   Yu X.-J., Wang H.-M., Ernberg I., Zeng Y.-X.;
RT   "Genomic sequence analysis of Epstein-Barr virus strain GD1 from a
RT   nasopharyngeal carcinoma patient.";
RL   J. Virol. 79:15323-15330(2005).
CC   -!- FUNCTION: Participates in viral evasion from HLA class I-restricted T-
CC       cell immunity. Associates with host TAP1 and TAP2 and prevents TAP-
CC       mediated peptide transport and subsequent loading.
CC   -!- SUBUNIT: Interacts with host TAP1 and TAP2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the lymphocryptovirus BNLF2a family.
CC       {ECO:0000305}.
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DR   EMBL; AY961628; AAY41159.1; -; Genomic_DNA.
DR   RefSeq; YP_401721.1; NC_007605.1.
DR   SMR; P0C738; -.
DR   IntAct; P0C738; 13.
DR   MINT; P0C738; -.
DR   DNASU; 3783720; -.
DR   GeneID; 3783720; -.
DR   KEGG; vg:3783720; -.
DR   Proteomes; UP000007641; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0039588; P:suppression by virus of host antigen processing and presentation; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Host endoplasmic reticulum; Host membrane; Host-virus interaction;
KW   Inhibition of host adaptive immune response by virus;
KW   Inhibition of host TAP by virus; Membrane; Transmembrane;
KW   Transmembrane helix; Viral immunoevasion.
FT   CHAIN           1..60
FT                   /note="Protein BNLF2a"
FT                   /id="PRO_0000382429"
FT   TRANSMEM        41..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          14..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   60 AA;  6540 MW;  19EAE809410982EA CRC64;
     MVHVLERALL EQQSSACGLP GSSTETRPSH PCPEDPDVSR LRLLLVVLCV LFGLLCLLLI