ID   ABRA_PLAF7              Reviewed;         743 AA.
AC   Q8I5D2;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=101 kDa malaria antigen;
DE   AltName: Full=Acidic basic repeat antigen;
DE   AltName: Full=p101;
GN   Name=ABRA; ORFNames=PFL1385c;
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
CC   -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000250}. Parasitophorous
CC       vacuole {ECO:0000250}. Note=At the merozoite surface and within the
CC       parasitophorous vacuole. {ECO:0000250}.
CC   -!- PTM: Not glycosylated. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the plasmodium ABRA family. {ECO:0000305}.
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DR   EMBL; AE014188; AAN36363.1; -; Genomic_DNA.
DR   RefSeq; XP_001350683.1; XM_001350647.1.
DR   PDB; 2MU9; NMR; -; A=161-180.
DR   PDBsum; 2MU9; -.
DR   AlphaFoldDB; Q8I5D2; -.
DR   BMRB; Q8I5D2; -.
DR   SMR; Q8I5D2; -.
DR   BioGRID; 1206700; 45.
DR   IntAct; Q8I5D2; 39.
DR   STRING; 5833.PFL1385c; -.
DR   PRIDE; Q8I5D2; -.
DR   EnsemblProtists; CZT99445; CZT99445; PF3D7_1228600.
DR   GeneID; 811329; -.
DR   KEGG; pfa:PF3D7_1228600; -.
DR   VEuPathDB; PlasmoDB:PF3D7_1228600; -.
DR   HOGENOM; CLU_374079_0_0_1; -.
DR   InParanoid; Q8I5D2; -.
DR   OMA; MKECKHL; -.
DR   PhylomeDB; Q8I5D2; -.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IDA:GeneDB.
DR   GO; GO:0020003; C:symbiont-containing vacuole; IDA:GeneDB.
PE   1: Evidence at protein level;
KW   3D-structure; Malaria; Repeat.
FT   CHAIN           1..743
FT                   /note="101 kDa malaria antigen"
FT                   /id="PRO_0000233385"
FT   REPEAT          226..231
FT                   /note="1"
FT   REPEAT          232..237
FT                   /note="2"
FT   REPEAT          238..243
FT                   /note="3"
FT   REPEAT          244..249
FT                   /note="4"
FT   REPEAT          250..255
FT                   /note="5"
FT   REPEAT          256..261
FT                   /note="6"
FT   REPEAT          262..267
FT                   /note="7"
FT   REPEAT          268..273
FT                   /note="8"
FT   REGION          202..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          226..273
FT                   /note="8 X 6 AA tandem repeats of [VT]-N-D-[ED]-[ED]-D"
FT   REGION          459..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          512..540
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          666..743
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..221
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..273
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        459..473
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        512..528
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        667..717
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        718..735
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   HELIX           166..177
FT                   /evidence="ECO:0007829|PDB:2MU9"
SQ   SEQUENCE   743 AA;  86623 MW;  F5D0C31C3816B0D9 CRC64;
     MMNMKIVLFS LLLFVIRWNI ISCNKNDKNQ GVDMNVLNNY ENLFKFVKCE YCNEHTYVKG
     KKAPSDPQCA DIKEECKELL KEKQYTDSVT YLMDGFKSAN NSANNGKKNN AEEMKNLVNF
     LQSHKKLIKA LKKNIESIQN KKHLIYKNKS YNPLLLSCVK KMNMLKENVD YIQKNQNLFK
     ELMNQKATYS FVNTKKKIIS LKSQGHKKET SQNQNENNDN QKYQEVNDED DVNDEEDTND
     DEDTNDEEDT NDDEDTNDDE DTNDEEDTND EEDHENNNAT AYELGIVPVN DVLNVNMKNM
     ITGNNFMDVV KNTLAQSGGL GSNDLINFLN QGKEIGENLL NITKMNLGDK NNLESFPLDE
     LNMLKDNLIN YEFILDNLKT SVLNKLKDLL LRLLYKAYVS YKKRKAQEKG LPEPTVTNEE
     YVEELKKGIL DMGIKLLFSK VKSLLKKLKN KIFPKKKEDN QAVDTKSMEE PKVKAQPALR
     GVEPTEDSNI MNSINNVMDE IDFFEKELIE NNNTPNVVPP TQSKKKNKNE TVSGMDENFD
     NHPENYFKEE YYYDENDDME VKVKKIGVTL KKFEPLKNGN VSETIKLIHL GNKDKKHIEA
     INNDIQIIKQ ELQAIYNELM NYTNGNKNIQ QIFQQNILEN DVLNQETEEE MEKQVEAITK
     QIEAEVDALA PKNKEEEEKE KEKEEKEKEE KEKEKEEKEK EEKEKEEKEK EEKEEEKKEK
     EEEQEEEEEE EIVPENLTTE ESK