ID   SYR_SULTO               Reviewed;         623 AA.
AC   Q971X1; F9VNZ0;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Arginine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            EC=6.1.1.19 {ECO:0000255|HAMAP-Rule:MF_00123};
DE   AltName: Full=Arginyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            Short=ArgRS {ECO:0000255|HAMAP-Rule:MF_00123};
GN   Name=argS {ECO:0000255|HAMAP-Rule:MF_00123}; OrderedLocusNames=STK_12580;
OS   Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
OS   (Sulfolobus tokodaii).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfurisphaera.
OX   NCBI_TaxID=273063;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16993 / JCM 10545 / NBRC 100140 / 7;
RX   PubMed=11572479; DOI=10.1093/dnares/8.4.123;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Jin-no K., Takahashi M., Sekine M.,
RA   Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y.,
RA   Nishijima K., Otsuka R., Nakazawa H., Takamiya M., Kato Y., Yoshizawa T.,
RA   Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K.,
RA   Masuda S., Yanagii M., Nishimura M., Yamagishi A., Oshima T., Kikuchi H.;
RT   "Complete genome sequence of an aerobic thermoacidophilic Crenarchaeon,
RT   Sulfolobus tokodaii strain7.";
RL   DNA Res. 8:123-140(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC         tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC         COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC         EC=6.1.1.19; Evidence={ECO:0000255|HAMAP-Rule:MF_00123};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00123}.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00123}.
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DR   EMBL; BA000023; BAK54498.1; -; Genomic_DNA.
DR   RefSeq; WP_010979277.1; NC_003106.2.
DR   AlphaFoldDB; Q971X1; -.
DR   SMR; Q971X1; -.
DR   STRING; 273063.STK_12580; -.
DR   EnsemblBacteria; BAK54498; BAK54498; STK_12580.
DR   GeneID; 1459256; -.
DR   KEGG; sto:STK_12580; -.
DR   PATRIC; fig|273063.9.peg.1416; -.
DR   eggNOG; arCOG00487; Archaea.
DR   OMA; NKPLHLG; -.
DR   OrthoDB; 7046at2157; -.
DR   Proteomes; UP000001015; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006420; P:arginyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR   CDD; cd00671; ArgRS_core; 1.
DR   Gene3D; 3.30.1360.70; -; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_00123; Arg_tRNA_synth; 1.
DR   InterPro; IPR001278; Arg-tRNA-ligase.
DR   InterPro; IPR036695; Arg-tRNA-synth_N_sf.
DR   InterPro; IPR035684; ArgRS_core.
DR   InterPro; IPR008909; DALR_anticod-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   PANTHER; PTHR11956; PTHR11956; 1.
DR   Pfam; PF05746; DALR_1; 1.
DR   Pfam; PF00750; tRNA-synt_1d; 1.
DR   PRINTS; PR01038; TRNASYNTHARG.
DR   SMART; SM00836; DALR_1; 1.
DR   SUPFAM; SSF47323; SSF47323; 1.
DR   SUPFAM; SSF55190; SSF55190; 1.
DR   TIGRFAMs; TIGR00456; argS; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..623
FT                   /note="Arginine--tRNA ligase"
FT                   /id="PRO_0000151657"
FT   MOTIF           116..126
FT                   /note="'HIGH' region"
SQ   SEQUENCE   623 AA;  71693 MW;  A24645D0996B038B CRC64;
     MNPIKEVKLE FAKILSERLS IDQNKIYENF EYPPKEQMGD VSLPLPTVTK NKELLNISDF
     PSGGKLIREI KKAGIYINGV INESELFKLI FTNFPEDYGI EKIQKPQRVV VEHTSANPIH
     PLHVGHLRNA ILGDVIARML KARGHEVNTR FYVNDAGRQV AILTLGYLLL GEPNPPRDEK
     IDQWIGVIYA ITNILIEINQ LKKELSSSNE EEYRQKISKL DELISLAGKH REKYPEIFDK
     LADEISKIEN IEEKIQNIIK NYERHSDEKI VNVIRKLVNW TLEGFKDSLK ILDIHFDNFD
     YESDLLWSKR VDEIVKLALS SKNIKEHKGT IALSLDLDPE ARKRLNIPLG LELPPLVLVR
     SDGTTLYTTR DIAYSLYKFE VFYANKVINV IAEQQSVPQM QLRASLYLLG FKDIAENLIH
     YSYGMVNLQG MRMSGRLGRY ISLDEIINEV KEVAENKIKE KGGDLNNLLD IVNSAIRYAI
     LSVSANKPVS FNIKNIVDFD QNSGPYLQYT YARAYNILAK NEEKLDINKV DFSDIVDDKR
     RLLISIAKFP EVATKAVDEL RPEDLLGFMR SIADIFNRWY NFERVLQEPN EGKRMLRLFI
     VKGVERILYN GLSIVGIKPL KRM