ID   SYR_THEKO               Reviewed;         642 AA.
AC   Q5JGH7;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Arginine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            EC=6.1.1.19 {ECO:0000255|HAMAP-Rule:MF_00123};
DE   AltName: Full=Arginyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00123};
DE            Short=ArgRS {ECO:0000255|HAMAP-Rule:MF_00123};
GN   Name=argS {ECO:0000255|HAMAP-Rule:MF_00123}; OrderedLocusNames=TK1235;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC         tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC         COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC         EC=6.1.1.19; Evidence={ECO:0000255|HAMAP-Rule:MF_00123};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00123}.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00123}.
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DR   EMBL; AP006878; BAD85424.1; -; Genomic_DNA.
DR   RefSeq; WP_011250186.1; NC_006624.1.
DR   AlphaFoldDB; Q5JGH7; -.
DR   SMR; Q5JGH7; -.
DR   STRING; 69014.TK1235; -.
DR   EnsemblBacteria; BAD85424; BAD85424; TK1235.
DR   GeneID; 3234303; -.
DR   KEGG; tko:TK1235; -.
DR   PATRIC; fig|69014.16.peg.1209; -.
DR   eggNOG; arCOG00487; Archaea.
DR   HOGENOM; CLU_006406_6_1_2; -.
DR   InParanoid; Q5JGH7; -.
DR   OMA; NKPLHLG; -.
DR   OrthoDB; 7046at2157; -.
DR   PhylomeDB; Q5JGH7; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004814; F:arginine-tRNA ligase activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006420; P:arginyl-tRNA aminoacylation; IBA:GO_Central.
DR   CDD; cd00671; ArgRS_core; 1.
DR   Gene3D; 3.30.1360.70; -; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_00123; Arg_tRNA_synth; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR001278; Arg-tRNA-ligase.
DR   InterPro; IPR005148; Arg-tRNA-synth_N.
DR   InterPro; IPR036695; Arg-tRNA-synth_N_sf.
DR   InterPro; IPR035684; ArgRS_core.
DR   InterPro; IPR008909; DALR_anticod-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   PANTHER; PTHR11956; PTHR11956; 1.
DR   Pfam; PF03485; Arg_tRNA_synt_N; 1.
DR   Pfam; PF05746; DALR_1; 1.
DR   Pfam; PF00750; tRNA-synt_1d; 2.
DR   PRINTS; PR01038; TRNASYNTHARG.
DR   SMART; SM01016; Arg_tRNA_synt_N; 1.
DR   SMART; SM00836; DALR_1; 1.
DR   SUPFAM; SSF47323; SSF47323; 1.
DR   SUPFAM; SSF55190; SSF55190; 1.
DR   TIGRFAMs; TIGR00456; argS; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..642
FT                   /note="Arginine--tRNA ligase"
FT                   /id="PRO_0000151654"
FT   MOTIF           133..143
FT                   /note="'HIGH' region"
SQ   SEQUENCE   642 AA;  73657 MW;  FDE442F1E63B933A CRC64;
     MVYKEVQERV RLALRQALDE MLHEAGKEWD GEITFDDTPS IELGDFGTAV SFQLARVFRK
     APKFIAEELV GRVKEKLPEE IRDVKAVNGY INFYLDYEFF GKALVREILE KGEKYGESEL
     GSGKKVIVEH TSVNPTKPLH MGHARNAVLG DTMARIMRKL GYTVEVQNYI DDLGVQFAQV
     LWGYLNLKEE FERIEAELRE KGLKEDFIDH VMGLLYVEVN KKLEENPEVD KEVRELMKKL
     EEGDNEIAEV GRKLAERVVR AQMLTTYRMG ITYDLLSWES DIMKSGIFGE AYGLIEKNEN
     FFWATEGKYK GAFVMDLRKL FPDMKNPFLV LRRSDGTATY TGKDIAYHLW KFGKVKADML
     YKLWDRVEDH ETWTTAPDGK EMPGKFGRAD IVINVIGAEQ KHPQMAIKYA LQLLGFEDAA
     ENFHHLAYEH VVRPEGSFSG RKGTWVGFTV DEVLNEAVQR ARELVEQKNP NLSDEEKDEI
     AEAVGVGAVR YNLVKYSPDK VITFRWEDVL NFEGDSAPYL QYAHARCASI LRKAEESGVE
     TDWNALLEKA DFSKLTNREK ELIKFLAKFP EVLESAGRDV KPHLVPAYLN ELASLFNRFY
     MDHPVLKAEE GIREERLLLV LAVKQVLRNG LDVLGIKAPE RM