ID   SYR_TREPA               Reviewed;         589 AA.
AC   O83803;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=Arginine--tRNA ligase;
DE            EC=6.1.1.19;
DE   AltName: Full=Arginyl-tRNA synthetase;
DE            Short=ArgRS;
GN   Name=argS; OrderedLocusNames=TP_0831;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC         tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC         COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC         EC=6.1.1.19;
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000305}.
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DR   EMBL; AE000520; AAC65797.1; -; Genomic_DNA.
DR   PIR; A71277; A71277.
DR   RefSeq; WP_010882275.1; NC_021490.2.
DR   AlphaFoldDB; O83803; -.
DR   SMR; O83803; -.
DR   IntAct; O83803; 4.
DR   STRING; 243276.TPANIC_0831; -.
DR   EnsemblBacteria; AAC65797; AAC65797; TP_0831.
DR   KEGG; tpa:TP_0831; -.
DR   eggNOG; COG0018; Bacteria.
DR   HOGENOM; CLU_006406_6_1_12; -.
DR   OMA; NKPLHLG; -.
DR   OrthoDB; 1146366at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006420; P:arginyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR   CDD; cd00671; ArgRS_core; 1.
DR   Gene3D; 3.30.1360.70; -; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_00123; Arg_tRNA_synth; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR001278; Arg-tRNA-ligase.
DR   InterPro; IPR005148; Arg-tRNA-synth_N.
DR   InterPro; IPR036695; Arg-tRNA-synth_N_sf.
DR   InterPro; IPR035684; ArgRS_core.
DR   InterPro; IPR008909; DALR_anticod-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   PANTHER; PTHR11956; PTHR11956; 1.
DR   Pfam; PF03485; Arg_tRNA_synt_N; 1.
DR   Pfam; PF05746; DALR_1; 1.
DR   Pfam; PF00750; tRNA-synt_1d; 1.
DR   PRINTS; PR01038; TRNASYNTHARG.
DR   SMART; SM01016; Arg_tRNA_synt_N; 1.
DR   SMART; SM00836; DALR_1; 1.
DR   SUPFAM; SSF47323; SSF47323; 1.
DR   SUPFAM; SSF55190; SSF55190; 1.
DR   TIGRFAMs; TIGR00456; argS; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..589
FT                   /note="Arginine--tRNA ligase"
FT                   /id="PRO_0000151630"
FT   MOTIF           132..142
FT                   /note="'HIGH' region"
SQ   SEQUENCE   589 AA;  67132 MW;  FA6156A69F4568E3 CRC64;
     MQDLCEMWRH AVARVLSQLQ GPAVEPVEGA QLVMEEPPEP GMGDIAFPLF LFAKRVRRSP
     AQLAQQLCTL LEEDTSMCAY GTPQARGPYL NVFLNKECVA AHTLDAIFAQ GERYGHTQYL
     QGKRIMVEFS SPNTNKPLHV GHLRNNAIGE SLSRIIAFCG ADVFKVNIIN DRGVHICKSM
     CAYQKFAHGK TPAHTGIKSD RFVGDWYVQF NRYAQQYPEE AEHDVRDLLQ RWESADPHVR
     ALWRTMNEWA LRGIKQTYER TGISFDKLYF ESETYTKGRE EVRRGLACGV FYQMEDNSIW
     VDLSSLGLDK KALLRSDGTT MYITQDIGTA IFRAQDWPFD QLLYVVGNEQ NYHFKVLFFV
     LRLLGYPWAQ QLHHVSYGMV NLPHGRMKSR EGTVVDADDI LDRLHSAAEE EIAKKGRENA
     LKHAQCIAEN VAIAALHYFL LQVSPQKDMV FHPEESLSFN GNTGPYLQYM GARISSLLKK
     VQEDVEQKGP REVRCDPALL THEAEWELVK ALARFPACVT RAAQGHDPSV ITGYLYTLSK
     SFSRFYHDCP ILCEARPDYA CARLELVRAV RIVLRTAMRL VLIPFLEEM