ID   BNPL1_CROOA             Reviewed;          32 AA.
AC   B3EWY3;
DT   06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2013, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Natriuretic peptide Coa_NP1 {ECO:0000303|Ref.1};
OS   Crotalus oreganus abyssus (Grand Canyon rattlesnake) (Crotalus abyssus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX   NCBI_TaxID=128077;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom {ECO:0000269|Ref.1};
RX   DOI=10.1007/s10989-011-9254-z;
RA   Da Silva S.L., Almeida J.R., Resende L.M., Martins W., Henriques F.A.F.A.,
RA   Baldasso P.A., Soares A.M., Taranto A.G., Resende R.R., Marangoni S.,
RA   Dias-Junior C.A.;
RT   "Isolation and characterization of a natriuretic peptide from Crotalus
RT   oreganus abyssus (Grand canyon rattlesnake) and its effects on systemic
RT   blood pressure and nitrite levels.";
RL   Int. J. Pept. Res. Ther. 17:165-173(2011).
CC   -!- FUNCTION: Snake venom natriuretic peptide that exhibits hypotensive and
CC       vasodepressor activity in rats. {ECO:0000269|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
CC   -!- MASS SPECTROMETRY: Mass=3510.98; Method=MALDI;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- MISCELLANEOUS: Vasodilation does not appear to be mediated by the
CC       natriuretic peptide receptor-A (NPR1) (Ref.1).
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. Snake NP
CC       subfamily. {ECO:0000255}.
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DR   AlphaFoldDB; B3EWY3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0097746; P:blood vessel diameter maintenance; IDA:UniProtKB.
DR   GO; GO:0008217; P:regulation of blood pressure; IDA:UniProtKB.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   InterPro; IPR002408; Natriuretic_peptide_brain.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00712; BNATPEPTIDE.
DR   PRINTS; PR00710; NATPEPTIDES.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hypotensive agent; Secreted;
KW   Toxin; Vasoactive; Vasodilator.
FT   PEPTIDE         1..32
FT                   /note="Natriuretic peptide Coa_NP1"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000421177"
FT   DISULFID        8..24
FT                   /evidence="ECO:0000250|UniProtKB:P83228"
SQ   SEQUENCE   32 AA;  3511 MW;  1730BF949E72B23F CRC64;
     SKRLSNGCFG LKLDRIGAMS GLGCWRLINE SK