ID   SYS1_DICDI              Reviewed;         232 AA.
AC   Q55E69;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Protein SYS1 homolog;
GN   Name=sys1; ORFNames=DDB_G0269368;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in protein trafficking. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SYS1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72034.1; -; Genomic_DNA.
DR   RefSeq; XP_645912.1; XM_640820.1.
DR   AlphaFoldDB; Q55E69; -.
DR   STRING; 44689.DDB0190211; -.
DR   PaxDb; Q55E69; -.
DR   EnsemblProtists; EAL72034; EAL72034; DDB_G0269368.
DR   GeneID; 8616853; -.
DR   KEGG; ddi:DDB_G0269368; -.
DR   dictyBase; DDB_G0269368; -.
DR   eggNOG; KOG4697; Eukaryota.
DR   HOGENOM; CLU_1196724_0_0_1; -.
DR   InParanoid; Q55E69; -.
DR   OMA; MIGEYLC; -.
DR   PhylomeDB; Q55E69; -.
DR   Reactome; R-DDI-6811440; Retrograde transport at the Trans-Golgi-Network.
DR   PRO; PR:Q55E69; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:0006895; P:Golgi to endosome transport; IBA:GO_Central.
DR   GO; GO:0043001; P:Golgi to plasma membrane protein transport; IBA:GO_Central.
DR   GO; GO:0034067; P:protein localization to Golgi apparatus; IBA:GO_Central.
DR   InterPro; IPR019185; Integral_membrane_SYS1-rel.
DR   PANTHER; PTHR12952; PTHR12952; 1.
DR   Pfam; PF09801; SYS1; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..232
FT                   /note="Protein SYS1 homolog"
FT                   /id="PRO_0000329302"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          151..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   232 AA;  26074 MW;  B43553757C45CB24 CRC64;
     MFYKYNAWDP KLIIGQILSI QCLYYILLAG ILYLLDSMFS SSLSLEQMFE YQSINTHSQS
     GRVVMTAFLI NSLFGSFCLK YIVERSKKCL DHSATVTFIH FIIVWIVSGF PKTVVWWAIQ
     LIGMVIMAMI GEYLCMRKEL MDIPLQRGKD LDSTPITIPP SPHTSSPIMN PKNNSNGNSG
     SNNNNNNIFS NSINSSGGSS SSINSIGNSN NPYQPIELEI LTHQDKQDEH DD