ID   ABRA_PLAFC              Reviewed;         743 AA.
AC   P22620;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=101 kDa malaria antigen;
DE   AltName: Full=Acidic basic repeat antigen;
DE   AltName: Full=p101;
GN   Name=ABRA;
OS   Plasmodium falciparum (isolate Camp / Malaysia).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5835;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SUBCELLULAR LOCATION.
RX   PubMed=3042768; DOI=10.1016/s0021-9258(18)37973-0;
RA   Weber J.L., Lyon J.A., Wolff R.H., Hall T., Lowell G.H., Chulay J.D.;
RT   "Primary structure of a Plasmodium falciparum malaria antigen located at
RT   the merozoite surface and within the parasitophorous vacuole.";
RL   J. Biol. Chem. 263:11421-11425(1988).
CC   -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000269|PubMed:3042768}.
CC       Parasitophorous vacuole {ECO:0000269|PubMed:3042768}. Note=At the
CC       merozoite surface and within the parasitophorous vacuole.
CC   -!- PTM: Not glycosylated. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the plasmodium ABRA family. {ECO:0000305}.
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DR   EMBL; J03902; AAA29462.1; -; Genomic_DNA.
DR   PIR; A29232; A29232.
DR   AlphaFoldDB; P22620; -.
DR   BMRB; P22620; -.
DR   SMR; P22620; -.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0020003; C:symbiont-containing vacuole; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Malaria; Repeat.
FT   CHAIN           1..743
FT                   /note="101 kDa malaria antigen"
FT                   /id="PRO_0000217177"
FT   REPEAT          226..231
FT                   /note="1"
FT   REPEAT          232..237
FT                   /note="2"
FT   REPEAT          238..243
FT                   /note="3"
FT   REPEAT          244..249
FT                   /note="4"
FT   REPEAT          250..255
FT                   /note="5"
FT   REPEAT          256..261
FT                   /note="6"
FT   REPEAT          262..267
FT                   /note="7"
FT   REPEAT          268..273
FT                   /note="8"
FT   REGION          202..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          226..273
FT                   /note="8 X 6 AA tandem repeats of [VT]-N-D-[ED]-[ED]-D"
FT   REGION          459..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          512..540
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          666..743
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..221
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..273
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        459..473
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        512..528
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        667..718
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        719..735
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   743 AA;  86622 MW;  FBF0B0F8B07D922C CRC64;
     MMNMKIVLFS LLLFVIRWNI ISCNKNDKNQ GVDMNVLNNY ENLFKFVKCE YCNEHTYVKG
     KKAPSDPQCA DIKEECKELL KEKQYTDSVT YLMDGFKSAN NSANNGKKNN AEEMKNLVNF
     LQSHKKLIKA LKKNIESIQN KKHLIYKNKS YNPLLLSCVK KMNMLKENVD YIQKNQNLFK
     ELMNQKATYS FVNTKKKIIS LKSQGHKKET SQNQNENNDN QKYQEVNDED DVNDEEDTND
     DEDTNDEEDT NDDEDTNDDE DTNDEEDTND EEDHENNNAT AYELGIVPVN DVLNVNMKNM
     ITGNNFMDVV KNTLAQSGGL GSNDLINFLN QGKEIGENLL NITKMNLGDK NNLESFPLDE
     LNMLKDNLIN YEFILDNLKT SVLNKLKDLL LRLLYKAYVS YKKRKAQEKG LPEPTVTNEE
     YVEELKKGIL DMGIKLLFSK VKSLLKKLKN KIFPKKKEDN QAVDTKSMEE PKVKAQPALR
     GVEPTEDSNI MNSINNVMDE IDFFEKELIE NNNTPNVVPP TQSKKKNKNE TVSGMDENFD
     NHPENYFKEE YYYDENDDME VKVKKIGVTL KKFEPLKNGN VSETIKLIHL GNKDKKHIEA
     INNDIQIIKQ ELQAIYNELM NYTNGNKNIQ QIFQQNILEN DVLNQETEEE MEKQVEAITK
     QIEAEVDALA PKNKEEEEKE KEKEKEKEEK EKEEKEKEEK EKEKEEKEKE KEEKEEEKKE
     KEEEQEEEEE EIVPENLTTE ESK