SYS1_HUMAN
ID SYS1_HUMAN Reviewed; 156 AA.
AC Q8N2H4; C9JFB3; E1P620; Q5QPU7; Q96SD8; Q9BQZ2; Q9BQZ4; Q9H1F7;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Protein SYS1 homolog;
GN Name=SYS1; Synonyms=C20orf169;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Stavrides G.S., Huckle E.J., Deloukas P.;
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Embryo, and Thyroid;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Blood;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH ARFRP1.
RX PubMed=15077113; DOI=10.1038/ncb1120;
RA Behnia R., Panic B., Whyte J.R.C., Munro S.;
RT "Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal
RT acetylation and the membrane protein Sys1p.";
RL Nat. Cell Biol. 6:405-413(2004).
CC -!- FUNCTION: Involved in protein trafficking. May serve as a receptor for
CC ARFRP1.
CC -!- SUBUNIT: Interacts with ARFRP1. {ECO:0000269|PubMed:15077113}.
CC -!- INTERACTION:
CC Q8N2H4; Q6UXG8-3: BTNL9; NbExp=3; IntAct=EBI-13075176, EBI-17953245;
CC Q8N2H4; Q15125: EBP; NbExp=3; IntAct=EBI-13075176, EBI-3915253;
CC Q8N2H4; Q9NYP7: ELOVL5; NbExp=3; IntAct=EBI-13075176, EBI-11037623;
CC Q8N2H4; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-13075176, EBI-781551;
CC Q8N2H4; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-13075176, EBI-1052304;
CC Q8N2H4; P26951: IL3RA; NbExp=3; IntAct=EBI-13075176, EBI-1757512;
CC Q8N2H4; Q8N743: KIR3DL3; NbExp=3; IntAct=EBI-13075176, EBI-17272405;
CC Q8N2H4; Q8NI22: MCFD2; NbExp=3; IntAct=EBI-13075176, EBI-2689785;
CC Q8N2H4; O14880: MGST3; NbExp=3; IntAct=EBI-13075176, EBI-724754;
CC Q8N2H4; Q9Y676: MRPS18B; NbExp=3; IntAct=EBI-13075176, EBI-750085;
CC Q8N2H4; P15151: PVR; NbExp=3; IntAct=EBI-13075176, EBI-3919694;
CC Q8N2H4; O00560: SDCBP; NbExp=3; IntAct=EBI-13075176, EBI-727004;
CC Q8N2H4; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-13075176, EBI-10262251;
CC Q8N2H4; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-13075176, EBI-17295964;
CC Q8N2H4; Q96DZ7: TM4SF19; NbExp=3; IntAct=EBI-13075176, EBI-6448756;
CC Q8N2H4; Q9NWD8: TMEM248; NbExp=3; IntAct=EBI-13075176, EBI-10314986;
CC Q8N2H4; O43557: TNFSF14; NbExp=3; IntAct=EBI-13075176, EBI-524131;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:15077113}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15077113}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N2H4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N2H4-2; Sequence=VSP_044540;
CC -!- SIMILARITY: Belongs to the SYS1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC39448.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL591714; CAC39448.1; ALT_INIT; mRNA.
DR EMBL; AK075264; BAC11506.1; -; mRNA.
DR EMBL; AK172738; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL021578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW75847.1; -; Genomic_DNA.
DR EMBL; CH471077; EAW75857.1; -; Genomic_DNA.
DR EMBL; BC048286; AAH48286.1; -; mRNA.
DR CCDS; CCDS13351.1; -. [Q8N2H4-1]
DR CCDS; CCDS56192.1; -. [Q8N2H4-2]
DR RefSeq; NP_001093261.1; NM_001099791.2. [Q8N2H4-2]
DR RefSeq; NP_001184058.1; NM_001197129.1. [Q8N2H4-1]
DR RefSeq; NP_291020.1; NM_033542.3. [Q8N2H4-1]
DR AlphaFoldDB; Q8N2H4; -.
DR BioGRID; 318199; 32.
DR IntAct; Q8N2H4; 17.
DR STRING; 9606.ENSP00000243918; -.
DR iPTMnet; Q8N2H4; -.
DR PhosphoSitePlus; Q8N2H4; -.
DR BioMuta; SYS1; -.
DR DMDM; 51316873; -.
DR jPOST; Q8N2H4; -.
DR MassIVE; Q8N2H4; -.
DR MaxQB; Q8N2H4; -.
DR PaxDb; Q8N2H4; -.
DR PeptideAtlas; Q8N2H4; -.
DR PRIDE; Q8N2H4; -.
DR ProteomicsDB; 71700; -. [Q8N2H4-1]
DR ProteomicsDB; 9962; -.
DR TopDownProteomics; Q8N2H4-1; -. [Q8N2H4-1]
DR Antibodypedia; 57552; 68 antibodies from 16 providers.
DR DNASU; 90196; -.
DR Ensembl; ENST00000243918.10; ENSP00000243918.5; ENSG00000204070.10. [Q8N2H4-1]
DR Ensembl; ENST00000372727.5; ENSP00000361812.1; ENSG00000204070.10. [Q8N2H4-1]
DR Ensembl; ENST00000426004.5; ENSP00000416506.1; ENSG00000204070.10. [Q8N2H4-2]
DR GeneID; 90196; -.
DR KEGG; hsa:90196; -.
DR MANE-Select; ENST00000243918.10; ENSP00000243918.5; NM_033542.4; NP_291020.1.
DR UCSC; uc002xnv.4; human. [Q8N2H4-1]
DR CTD; 90196; -.
DR DisGeNET; 90196; -.
DR GeneCards; SYS1; -.
DR HGNC; HGNC:16162; SYS1.
DR HPA; ENSG00000204070; Low tissue specificity.
DR MIM; 612979; gene.
DR neXtProt; NX_Q8N2H4; -.
DR OpenTargets; ENSG00000204070; -.
DR PharmGKB; PA162405119; -.
DR VEuPathDB; HostDB:ENSG00000204070; -.
DR eggNOG; KOG4697; Eukaryota.
DR GeneTree; ENSGT00940000154347; -.
DR HOGENOM; CLU_081382_2_1_1; -.
DR InParanoid; Q8N2H4; -.
DR OMA; EYEMVGM; -.
DR OrthoDB; 1583277at2759; -.
DR PhylomeDB; Q8N2H4; -.
DR TreeFam; TF105875; -.
DR PathwayCommons; Q8N2H4; -.
DR Reactome; R-HSA-6811440; Retrograde transport at the Trans-Golgi-Network.
DR SignaLink; Q8N2H4; -.
DR BioGRID-ORCS; 90196; 655 hits in 1073 CRISPR screens.
DR GenomeRNAi; 90196; -.
DR Pharos; Q8N2H4; Tbio.
DR PRO; PR:Q8N2H4; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q8N2H4; protein.
DR Bgee; ENSG00000204070; Expressed in islet of Langerhans and 180 other tissues.
DR ExpressionAtlas; Q8N2H4; baseline and differential.
DR Genevisible; Q8N2H4; HS.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
DR GO; GO:0006895; P:Golgi to endosome transport; IBA:GO_Central.
DR GO; GO:0043001; P:Golgi to plasma membrane protein transport; IBA:GO_Central.
DR GO; GO:0034067; P:protein localization to Golgi apparatus; IBA:GO_Central.
DR InterPro; IPR016973; Integral_membrane_SYS1.
DR InterPro; IPR019185; Integral_membrane_SYS1-rel.
DR PANTHER; PTHR12952; PTHR12952; 1.
DR Pfam; PF09801; SYS1; 1.
DR PIRSF; PIRSF031402; SYS1_homologue; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..156
FT /note="Protein SYS1 homolog"
FT /id="PRO_0000213940"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 77..156
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044540"
SQ SEQUENCE 156 AA; 17615 MW; 541FBB6326C9C0BB CRC64;
MAGQFRSYVW DPLLILSQIV LMQTVYYGSL GLWLALVDGL VRSSPSLDQM FDAEILGFST
PPGRLSMMSF ILNALTCALG LLYFIRRGKQ CLDFTVTVHF FHLLGCWFYS SRFPSALTWW
LVQAVCIALM AVIGEYLCMR TELKEIPLNS APKSNV
