SYS1_MOUSE
ID SYS1_MOUSE Reviewed; 156 AA.
AC Q78S06; Q3UFU1; Q9DAU8;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Protein SYS1 homolog;
GN Name=Sys1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreas, Placenta, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in protein trafficking. May serve as a receptor for
CC ARFRP1 (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ARFRP1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SYS1 family. {ECO:0000305}.
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DR EMBL; AK003071; BAB22547.1; -; mRNA.
DR EMBL; AK005510; BAB24089.1; -; mRNA.
DR EMBL; AK075770; BAC35944.1; -; mRNA.
DR EMBL; AK148305; BAE28468.1; -; mRNA.
DR EMBL; BC061084; AAH61084.1; -; mRNA.
DR CCDS; CCDS50793.1; -.
DR RefSeq; NP_079851.2; NM_025575.3.
DR RefSeq; XP_011238034.1; XM_011239732.2.
DR RefSeq; XP_011238035.1; XM_011239733.1.
DR AlphaFoldDB; Q78S06; -.
DR SMR; Q78S06; -.
DR BioGRID; 211490; 2.
DR IntAct; Q78S06; 1.
DR STRING; 10090.ENSMUSP00000104976; -.
DR PhosphoSitePlus; Q78S06; -.
DR PaxDb; Q78S06; -.
DR PeptideAtlas; Q78S06; -.
DR PRIDE; Q78S06; -.
DR ProteomicsDB; 263191; -.
DR DNASU; 66460; -.
DR Ensembl; ENSMUST00000072452; ENSMUSP00000072275; ENSMUSG00000045503.
DR Ensembl; ENSMUST00000109352; ENSMUSP00000104976; ENSMUSG00000045503.
DR Ensembl; ENSMUST00000125086; ENSMUSP00000121900; ENSMUSG00000045503.
DR GeneID; 66460; -.
DR KEGG; mmu:66460; -.
DR UCSC; uc008nur.1; mouse.
DR CTD; 90196; -.
DR MGI; MGI:1913710; Sys1.
DR VEuPathDB; HostDB:ENSMUSG00000045503; -.
DR eggNOG; KOG4697; Eukaryota.
DR GeneTree; ENSGT00940000154347; -.
DR HOGENOM; CLU_081382_2_1_1; -.
DR InParanoid; Q78S06; -.
DR OMA; EYEMVGM; -.
DR OrthoDB; 1583277at2759; -.
DR PhylomeDB; Q78S06; -.
DR TreeFam; TF105875; -.
DR Reactome; R-MMU-6811440; Retrograde transport at the Trans-Golgi-Network.
DR BioGRID-ORCS; 66460; 29 hits in 73 CRISPR screens.
DR ChiTaRS; Sys1; mouse.
DR PRO; PR:Q78S06; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q78S06; protein.
DR Bgee; ENSMUSG00000045503; Expressed in facial nucleus and 252 other tissues.
DR ExpressionAtlas; Q78S06; baseline and differential.
DR Genevisible; Q78S06; MM.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0006895; P:Golgi to endosome transport; IBA:GO_Central.
DR GO; GO:0043001; P:Golgi to plasma membrane protein transport; IBA:GO_Central.
DR GO; GO:0034067; P:protein localization to Golgi apparatus; IBA:GO_Central.
DR InterPro; IPR016973; Integral_membrane_SYS1.
DR InterPro; IPR019185; Integral_membrane_SYS1-rel.
DR PANTHER; PTHR12952; PTHR12952; 1.
DR Pfam; PF09801; SYS1; 1.
DR PIRSF; PIRSF031402; SYS1_homologue; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..156
FT /note="Protein SYS1 homolog"
FT /id="PRO_0000213941"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 146
FT /note="I -> V (in Ref. 1; BAB24089)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 156 AA; 17554 MW; 814BC83146DD285B CRC64;
MAGQFRSYVW DPLLILSQIV LMQTVYYGSL GLWLALVDAL VRSSPSLDQM FDAEILGFST
PPGRLSMMSF VLNALTCALG LLYFIRRGKQ CLDFTVTVHF FHLLGCWLYS SRFPSALTWW
LVQAVCIALM AVIGEYLCMR TELKEIPLSS APKSNV
