ID   SYS1_NEMVE              Reviewed;         157 AA.
AC   A7S6Y0;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Protein SYS1 homolog;
GN   Name=sys1; ORFNames=v1g229542;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: Involved in protein trafficking. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SYS1 family. {ECO:0000305}.
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DR   EMBL; DS469590; EDO40540.1; -; Genomic_DNA.
DR   RefSeq; XP_001632603.1; XM_001632553.1.
DR   AlphaFoldDB; A7S6Y0; -.
DR   SMR; A7S6Y0; -.
DR   STRING; 45351.EDO40540; -.
DR   EnsemblMetazoa; EDO40540; EDO40540; NEMVEDRAFT_v1g229542.
DR   GeneID; 5512228; -.
DR   KEGG; nve:5512228; -.
DR   eggNOG; KOG4697; Eukaryota.
DR   HOGENOM; CLU_081382_2_1_1; -.
DR   InParanoid; A7S6Y0; -.
DR   OMA; EYEMVGM; -.
DR   OrthoDB; 1583277at2759; -.
DR   PhylomeDB; A7S6Y0; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:0006895; P:Golgi to endosome transport; IBA:GO_Central.
DR   GO; GO:0043001; P:Golgi to plasma membrane protein transport; IBA:GO_Central.
DR   GO; GO:0034067; P:protein localization to Golgi apparatus; IBA:GO_Central.
DR   InterPro; IPR016973; Integral_membrane_SYS1.
DR   InterPro; IPR019185; Integral_membrane_SYS1-rel.
DR   PANTHER; PTHR12952; PTHR12952; 1.
DR   Pfam; PF09801; SYS1; 1.
DR   PIRSF; PIRSF031402; SYS1_homologue; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..157
FT                   /note="Protein SYS1 homolog"
FT                   /id="PRO_0000329301"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   157 AA;  17574 MW;  0DA28BEC0C942064 CRC64;
     MAAGFRTNVW DPVLIISQII AIQCTFYISL GVWVLIVDYW SGSIHSLDQF FAYKELDISS
     LKGKLLMIAF CLNSLTGAMA LWFIVKRAKQ CLDFTTTAHI VHLVFCCIYA GFPFSWTWWL
     LNIICLALMA VIGEFVCMKT ELKAIKVSAG SSGKNSV