ID   SYS1_PONAB              Reviewed;         156 AA.
AC   A4K2W1;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Protein SYS1 homolog;
GN   Name=SYS1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=17267810; DOI=10.1101/gr.6004607;
RG   NISC comparative sequencing program;
RA   Hurle B., Swanson W., Green E.D.;
RT   "Comparative sequence analyses reveal rapid and divergent evolutionary
RT   changes of the WFDC locus in the primate lineage.";
RL   Genome Res. 17:276-286(2007).
CC   -!- FUNCTION: Involved in protein trafficking. May serve as a receptor for
CC       ARFRP1 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ARFRP1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SYS1 family. {ECO:0000305}.
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DR   EMBL; DP000045; ABO52996.1; -; Genomic_DNA.
DR   RefSeq; NP_001162048.1; NM_001168576.1.
DR   AlphaFoldDB; A4K2W1; -.
DR   Ensembl; ENSPPYT00000040006; ENSPPYP00000037840; ENSPPYG00000036501.
DR   GeneID; 100137180; -.
DR   KEGG; pon:100137180; -.
DR   CTD; 90196; -.
DR   GeneTree; ENSGT00940000154347; -.
DR   InParanoid; A4K2W1; -.
DR   OrthoDB; 1583277at2759; -.
DR   Proteomes; UP000001595; Chromosome 20.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR016973; Integral_membrane_SYS1.
DR   InterPro; IPR019185; Integral_membrane_SYS1-rel.
DR   PANTHER; PTHR12952; PTHR12952; 1.
DR   Pfam; PF09801; SYS1; 1.
DR   PIRSF; PIRSF031402; SYS1_homologue; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..156
FT                   /note="Protein SYS1 homolog"
FT                   /id="PRO_0000329298"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   156 AA;  17615 MW;  541FBB6326C9C0BB CRC64;
     MAGQFRSYVW DPLLILSQIV LMQTVYYGSL GLWLALVDGL VRSSPSLDQM FDAEILGFST
     PPGRLSMMSF ILNALTCALG LLYFIRRGKQ CLDFTVTVHF FHLLGCWFYS SRFPSALTWW
     LVQAVCIALM AVIGEYLCMR TELKEIPLNS APKSNV