ID   BOD1_MOUSE              Reviewed;         173 AA.
AC   Q5SQY2;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Biorientation of chromosomes in cell division protein 1;
DE   AltName: Full=Biorientation defective protein 1;
DE   AltName: Full=Protein FAM44B;
GN   Name=Bod1; Synonyms=Fam44b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: Required for proper chromosome biorientation through the
CC       detection or correction of syntelic attachments in mitotic spindles.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SET1B complex composed of the catalytic
CC       subunit SETD1B, WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1,
CC       DPY30 homotrimer and BOD1. {ECO:0000250|UniProtKB:Q96IK1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Chromosome, centromere, kinetochore
CC       {ECO:0000250}. Note=Localizes at the centrosomes throughout the cell
CC       cycle, only dissociating during cytokinesis. Localizes at the
CC       kinetochore from prometaphase until anaphase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BOD1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL713921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS24513.1; -.
DR   RefSeq; NP_001020090.1; NM_001024919.1.
DR   AlphaFoldDB; Q5SQY2; -.
DR   SMR; Q5SQY2; -.
DR   BioGRID; 213530; 9.
DR   IntAct; Q5SQY2; 8.
DR   STRING; 10090.ENSMUSP00000056417; -.
DR   iPTMnet; Q5SQY2; -.
DR   PhosphoSitePlus; Q5SQY2; -.
DR   EPD; Q5SQY2; -.
DR   MaxQB; Q5SQY2; -.
DR   PaxDb; Q5SQY2; -.
DR   PRIDE; Q5SQY2; -.
DR   ProteomicsDB; 273792; -.
DR   Ensembl; ENSMUST00000058060; ENSMUSP00000056417; ENSMUSG00000044502.
DR   Ensembl; ENSMUST00000109415; ENSMUSP00000105042; ENSMUSG00000044502.
DR   GeneID; 69556; -.
DR   KEGG; mmu:69556; -.
DR   UCSC; uc007iim.1; mouse.
DR   CTD; 91272; -.
DR   MGI; MGI:1916806; Bod1.
DR   VEuPathDB; HostDB:ENSMUSG00000044502; -.
DR   eggNOG; ENOG502S57W; Eukaryota.
DR   GeneTree; ENSGT00940000154979; -.
DR   HOGENOM; CLU_139504_0_0_1; -.
DR   InParanoid; Q5SQY2; -.
DR   OMA; IICQVVD; -.
DR   OrthoDB; 1333373at2759; -.
DR   PhylomeDB; Q5SQY2; -.
DR   TreeFam; TF325311; -.
DR   BioGRID-ORCS; 69556; 7 hits in 74 CRISPR screens.
DR   ChiTaRS; Bod1; mouse.
DR   PRO; PR:Q5SQY2; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q5SQY2; protein.
DR   Bgee; ENSMUSG00000044502; Expressed in secondary oocyte and 227 other tissues.
DR   Genevisible; Q5SQY2; MM.
DR   GO; GO:0005813; C:centrosome; ISO:MGI.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000940; C:outer kinetochore; ISO:MGI.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; ISO:MGI.
DR   GO; GO:0005876; C:spindle microtubule; ISO:MGI.
DR   GO; GO:0000922; C:spindle pole; ISO:MGI.
DR   GO; GO:0051721; F:protein phosphatase 2A binding; ISO:MGI.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; ISO:MGI.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0032515; P:negative regulation of phosphoprotein phosphatase activity; IBA:GO_Central.
DR   InterPro; IPR026955; Bod1-like.
DR   PANTHER; PTHR31532; PTHR31532; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Cytoplasm; Cytoskeleton;
KW   Kinetochore; Mitosis; Reference proteome.
FT   CHAIN           1..173
FT                   /note="Biorientation of chromosomes in cell division
FT                   protein 1"
FT                   /id="PRO_0000187029"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          148..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   173 AA;  18364 MW;  AD6C0364F0C0B69B CRC64;
     MADGAGAGAA GQASGPSGGS SGAGGPVNPA SLPPGDPQLI ALIVEQLKSR GLFDSFRRDC
     LADVDTKPAY QNLRQKVDNF VSTHLDKQEW NPAMNKNQLR NGLRQSVVQS GMLEAGVDRI
     ISQVVDPKLN HIFRPQIERA IHEFLAAQKK EAVPAPPPEP ESQDPPAPSQ DAS