ID   BOD1_RAT                Reviewed;         173 AA.
AC   Q6AYJ2;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Biorientation of chromosomes in cell division protein 1;
DE   AltName: Full=Biorientation defective protein 1;
DE   AltName: Full=Protein FAM44B;
GN   Name=Bod1; Synonyms=Fam44b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required for proper chromosome biorientation through the
CC       detection or correction of syntelic attachments in mitotic spindles.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SET1B complex composed of the catalytic
CC       subunit SETD1B, WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1,
CC       DPY30 homotrimer and BOD1. {ECO:0000250|UniProtKB:Q96IK1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Chromosome, centromere, kinetochore
CC       {ECO:0000250}. Note=Localizes at the centrosomes throughout the cell
CC       cycle, only dissociating during cytokinesis. Localizes at the
CC       kinetochore from prometaphase until anaphase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BOD1 family. {ECO:0000305}.
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DR   EMBL; BC079025; AAH79025.1; -; mRNA.
DR   RefSeq; NP_001013876.2; NM_001013854.1.
DR   AlphaFoldDB; Q6AYJ2; -.
DR   STRING; 10116.ENSRNOP00000028115; -.
DR   iPTMnet; Q6AYJ2; -.
DR   PhosphoSitePlus; Q6AYJ2; -.
DR   PaxDb; Q6AYJ2; -.
DR   GeneID; 287173; -.
DR   KEGG; rno:287173; -.
DR   UCSC; RGD:1305622; rat.
DR   CTD; 91272; -.
DR   RGD; 1305622; Bod1.
DR   eggNOG; ENOG502S57W; Eukaryota.
DR   HOGENOM; CLU_1170364_0_0_1; -.
DR   InParanoid; Q6AYJ2; -.
DR   OrthoDB; 1333373at2759; -.
DR   PhylomeDB; Q6AYJ2; -.
DR   TreeFam; TF325311; -.
DR   PRO; PR:Q6AYJ2; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; Q6AYJ2; RN.
DR   GO; GO:0005813; C:centrosome; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000940; C:outer kinetochore; ISO:RGD.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; ISO:RGD.
DR   GO; GO:0005876; C:spindle microtubule; ISO:RGD.
DR   GO; GO:0000922; C:spindle pole; ISO:RGD.
DR   GO; GO:0051721; F:protein phosphatase 2A binding; ISO:RGD.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; ISO:RGD.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007080; P:mitotic metaphase plate congression; ISO:RGD.
DR   GO; GO:1990758; P:mitotic sister chromatid biorientation; ISO:RGD.
DR   GO; GO:0071962; P:mitotic sister chromatid cohesion, centromeric; ISO:RGD.
DR   GO; GO:0032515; P:negative regulation of phosphoprotein phosphatase activity; ISO:RGD.
DR   GO; GO:0071459; P:protein localization to chromosome, centromeric region; ISO:RGD.
DR   InterPro; IPR026955; Bod1-like.
DR   PANTHER; PTHR31532; PTHR31532; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Cytoplasm; Cytoskeleton;
KW   Kinetochore; Mitosis; Reference proteome.
FT   CHAIN           1..173
FT                   /note="Biorientation of chromosomes in cell division
FT                   protein 1"
FT                   /id="PRO_0000187030"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          148..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   173 AA;  18352 MW;  F5D80B9B2E60600A CRC64;
     MADSAGAGAA GQASGPAGGS SGAGGTVNPA SLPPGDPQLI ALIVEQLKSR GLFDSFRRDC
     LADVDTKPAY QNLRQKVDNF VSTHLDKQEW NPAMNKNQLR NGLRQSVVQS GMLEAGVDRI
     ISQVVDPKLN HIFRPQIERA IHEFLAAQKK EAVPAPPPEP EGQDPPAPSQ DAS