ID   BOD1_XENTR              Reviewed;         169 AA.
AC   Q68FB1; Q28H68;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Biorientation of chromosomes in cell division protein 1;
DE   AltName: Full=Biorientation defective protein 1;
DE   AltName: Full=Protein FAM44B;
GN   Name=bod1; Synonyms=fam44b; ORFNames=TEgg028l03.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for proper chromosome biorientation through the
CC       detection or correction of syntelic attachments in mitotic spindles.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Chromosome, centromere, kinetochore
CC       {ECO:0000250}. Note=Localizes at the centrosomes throughout the cell
CC       cycle, only dissociating during cytokinesis. Localizes at the
CC       kinetochore from prometaphase until anaphase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BOD1 family. {ECO:0000305}.
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DR   EMBL; CR761021; CAJ81950.1; -; mRNA.
DR   EMBL; BC079931; AAH79931.1; -; mRNA.
DR   RefSeq; NP_001007495.1; NM_001007494.1.
DR   RefSeq; XP_012810034.1; XM_012954580.2.
DR   RefSeq; XP_012810035.1; XM_012954581.2.
DR   RefSeq; XP_012810036.1; XM_012954582.2.
DR   RefSeq; XP_012810037.1; XM_012954583.2.
DR   RefSeq; XP_017945730.1; XM_018090241.1.
DR   AlphaFoldDB; Q68FB1; -.
DR   SMR; Q68FB1; -.
DR   STRING; 8364.ENSXETP00000048799; -.
DR   PaxDb; Q68FB1; -.
DR   DNASU; 493221; -.
DR   Ensembl; ENSXETT00000048799; ENSXETP00000048799; ENSXETG00000022543.
DR   GeneID; 493221; -.
DR   KEGG; xtr:493221; -.
DR   CTD; 91272; -.
DR   Xenbase; XB-GENE-5810100; bod1.
DR   eggNOG; ENOG502S57W; Eukaryota.
DR   HOGENOM; CLU_139504_0_0_1; -.
DR   InParanoid; Q68FB1; -.
DR   OMA; HLNTQDW; -.
DR   OrthoDB; 1333373at2759; -.
DR   PhylomeDB; Q68FB1; -.
DR   TreeFam; TF325311; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000022543; Expressed in 2-cell stage embryo and 14 other tissues.
DR   ExpressionAtlas; Q68FB1; differential.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000940; C:outer kinetochore; IBA:GO_Central.
DR   GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR   GO; GO:0000922; C:spindle pole; IBA:GO_Central.
DR   GO; GO:0051721; F:protein phosphatase 2A binding; IBA:GO_Central.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0032515; P:negative regulation of phosphoprotein phosphatase activity; IBA:GO_Central.
DR   InterPro; IPR026955; Bod1-like.
DR   PANTHER; PTHR31532; PTHR31532; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Cytoplasm; Cytoskeleton;
KW   Kinetochore; Mitosis; Reference proteome.
FT   CHAIN           1..169
FT                   /note="Biorientation of chromosomes in cell division
FT                   protein 1"
FT                   /id="PRO_0000187032"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          136..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..161
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   169 AA;  18256 MW;  0CACE74EF87A1FA2 CRC64;
     MAESGSGAGS GSSSVGGVSN PTSLAPGDSQ LIALIVEQLK SRGQFDGFRR DCLADVDTKP
     AYQNLRQKVD NFVSTHLDKQ EWNADMNKNQ LRNGLRQSVI QSGMLEAGVD RIISQVVDPK
     LNHIFRPQIE KAIQEYLAAQ TKEEPAPPLP PGPPEPQEQE PPGPSQSVS