ID   BOKA_DANRE              Reviewed;         221 AA.
AC   Q6DC66;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Bcl-2-related ovarian killer protein homolog A {ECO:0000305};
DE            Short=zBok1;
GN   Name=boka {ECO:0000312|ZFIN:ZDB-GENE-040801-131};
GN   Synonyms=bok {ECO:0000312|ZFIN:ZDB-GENE-040801-131}; ORFNames=zgc:100979;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAH78217.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH78217.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   FUNCTION, DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX   PubMed=16888646; DOI=10.1038/sj.cdd.4402016;
RA   Kratz E., Eimon P.M., Mukhyala K., Stern H., Zha J., Strasser A., Hart R.,
RA   Ashkenazi A.;
RT   "Functional characterization of the Bcl-2 gene family in the zebrafish.";
RL   Cell Death Differ. 13:1631-1640(2006).
CC   -!- FUNCTION: May play a role in apoptosis. Does not appear to show pro-
CC       apoptotic activity when expressed ectopically in early embryos.
CC       {ECO:0000269|PubMed:16888646}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9UMX3}; Single-
CC       pass membrane protein {ECO:0000250|UniProtKB:O35425}.
CC   -!- TISSUE SPECIFICITY: Strongest expression in ovary and eye, weaker
CC       expression in gut, kidney and brain. Little expression in liver or
CC       heart. {ECO:0000269|PubMed:16888646}.
CC   -!- DEVELOPMENTAL STAGE: Not expressed maternally. Zygotic expression from
CC       24-72 hours post-fertilization (hpf). Also expressed in adult.
CC       {ECO:0000269|PubMed:16888646}.
CC   -!- SIMILARITY: Belongs to the Bcl-2 family. {ECO:0000255}.
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DR   EMBL; BC078217; AAH78217.1; -; mRNA.
DR   AlphaFoldDB; Q6DC66; -.
DR   SMR; Q6DC66; -.
DR   STRING; 7955.ENSDARP00000123964; -.
DR   PaxDb; Q6DC66; -.
DR   ZFIN; ZDB-GENE-040801-131; boka.
DR   eggNOG; KOG4728; Eukaryota.
DR   InParanoid; Q6DC66; -.
DR   PhylomeDB; Q6DC66; -.
DR   ChiTaRS; boka; zebrafish.
DR   PRO; PR:Q6DC66; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0046982; F:protein heterodimerization activity; IBA:GO_Central.
DR   GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
DR   GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IBA:GO_Central.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd06845; Bcl-2_like; 1.
DR   Gene3D; 1.10.437.10; -; 1.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR046371; Bcl-2_BH1-3.
DR   InterPro; IPR026298; Bcl-2_fam.
DR   InterPro; IPR002475; Bcl2-like.
DR   InterPro; IPR026309; BOK.
DR   PANTHER; PTHR11256; PTHR11256; 1.
DR   PANTHER; PTHR11256:SF48; PTHR11256:SF48; 1.
DR   Pfam; PF00452; Bcl-2; 1.
DR   SMART; SM00337; BCL; 1.
DR   SUPFAM; SSF56854; SSF56854; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..221
FT                   /note="Bcl-2-related ovarian killer protein homolog A"
FT                   /id="PRO_0000283818"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           32..44
FT                   /note="BH4"
FT                   /evidence="ECO:0000255"
FT   MOTIF           64..80
FT                   /note="BH3"
FT                   /evidence="ECO:0000255"
FT   MOTIF           110..140
FT                   /note="BH1"
FT                   /evidence="ECO:0000255"
FT   MOTIF           173..187
FT                   /note="BH2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   221 AA;  24599 MW;  1C60961C159C33AA CRC64;
     MEMLRRSSVF AAEVMEVFDR SPTDKELVSQ SKVLCRDYIH SRLHRAGIGW SKPEHGSGGT
     LAEVSSVLLW LGDELEYLRP NVYRNVARQL NITIASENIV SDAFLAVAAE IFSTEYSRKG
     LEKHKGVTWG KIVSLYAVAG ALAVDCVRNG HPAMVHTIVD CMGEFVRKSL ASWLKKRGGW
     ADITKCVVST DPSFHSHWLV TAACACGHYL KAVVFYLLRE K