ID   BOKB_DANRE              Reviewed;         211 AA.
AC   Q7T381; Q0GKC3;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Bcl-2-related ovarian killer protein homolog B {ECO:0000305};
DE            Short=zBok2 {ECO:0000303|PubMed:16888646};
GN   Name=bokb; Synonyms=bok; ORFNames=zgc:64041;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=16888646; DOI=10.1038/sj.cdd.4402016;
RA   Kratz E., Eimon P.M., Mukhyala K., Stern H., Zha J., Strasser A., Hart R.,
RA   Ashkenazi A.;
RT   "Functional characterization of the Bcl-2 gene family in the zebrafish.";
RL   Cell Death Differ. 13:1631-1640(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in apoptosis. Does not appear to show pro-
CC       apoptotic activity when expressed ectopically in early embryos.
CC       {ECO:0000269|PubMed:16888646}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9UMX3}; Single-
CC       pass membrane protein {ECO:0000250|UniProtKB:O35425}.
CC   -!- TISSUE SPECIFICITY: Expressed strongly in ovary and more weakly in eye.
CC       Little expression in other tissues examined.
CC       {ECO:0000269|PubMed:16888646}.
CC   -!- DEVELOPMENTAL STAGE: Expressed maternally but largely absent later in
CC       embryonic development. Also expressed in adult.
CC       {ECO:0000269|PubMed:16888646}.
CC   -!- SIMILARITY: Belongs to the Bcl-2 family. {ECO:0000305}.
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DR   EMBL; DQ860157; ABI18128.1; -; mRNA.
DR   EMBL; BC053218; AAH53218.1; -; mRNA.
DR   RefSeq; NP_957479.1; NM_201185.1.
DR   AlphaFoldDB; Q7T381; -.
DR   SMR; Q7T381; -.
DR   STRING; 7955.ENSDARP00000123352; -.
DR   PaxDb; Q7T381; -.
DR   DNASU; 394160; -.
DR   GeneID; 394160; -.
DR   KEGG; dre:394160; -.
DR   CTD; 394160; -.
DR   ZFIN; ZDB-GENE-040426-1346; bokb.
DR   eggNOG; KOG4728; Eukaryota.
DR   InParanoid; Q7T381; -.
DR   OrthoDB; 1278637at2759; -.
DR   ChiTaRS; boka; zebrafish.
DR   PRO; PR:Q7T381; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0046982; F:protein heterodimerization activity; IBA:GO_Central.
DR   GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
DR   GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IBA:GO_Central.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd06845; Bcl-2_like; 1.
DR   Gene3D; 1.10.437.10; -; 1.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR046371; Bcl-2_BH1-3.
DR   InterPro; IPR026298; Bcl-2_fam.
DR   InterPro; IPR002475; Bcl2-like.
DR   InterPro; IPR003093; Bcl2_BH4.
DR   InterPro; IPR026309; BOK.
DR   PANTHER; PTHR11256; PTHR11256; 1.
DR   PANTHER; PTHR11256:SF48; PTHR11256:SF48; 1.
DR   Pfam; PF00452; Bcl-2; 1.
DR   PRINTS; PR01862; BCL2FAMILY.
DR   SMART; SM00337; BCL; 1.
DR   SUPFAM; SSF56854; SSF56854; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
DR   PROSITE; PS50063; BH4_2; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..211
FT                   /note="Bcl-2-related ovarian killer protein homolog B"
FT                   /id="PRO_0000143090"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           32..44
FT                   /note="BH4"
FT   MOTIF           67..83
FT                   /note="BH3"
FT   MOTIF           113..132
FT                   /note="BH1"
FT   MOTIF           165..179
FT                   /note="BH2"
SQ   SEQUENCE   211 AA;  23834 MW;  4FE09F1ABDA0D561 CRC64;
     MNVFARSSVL AAEMIDVFDR THTEKELVFQ SKELCRDFIH SRITREGLSW SKVELDLPEP
     RGVLVDVSVV LLKLGDELEC MRPYVYRNIA KQLNISVSVE AVVSDAFLSV ATEVIAMGIT
     WGKVVAIYAV AAGLAVDCVR LGHPVMVHTI VDSLGEFVRR SLVPWLKKRG GWVDILKCVV
     NMDSRAHVHW LSTAVLTWRE FIKTMYVYLT K