BOL4_BOMPE
ID BOL4_BOMPE Reviewed; 17 AA.
AC P07495;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1988, sequence version 1.
DT 25-MAY-2022, entry version 53.
DE RecName: Full=Bombolitin-4;
DE AltName: Full=Bombolitin IV;
OS Bombus pensylvanicus (American bumblebee) (Apis pensylvanica).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC Bombus; Fervidobombus.
OX NCBI_TaxID=28643;
RN [1]
RP PROTEIN SEQUENCE, AND AMIDATION AT VAL-17.
RC TISSUE=Venom;
RX PubMed=2578459; DOI=10.1016/s0021-9258(18)89611-9;
RA Argiolas A., Pisano J.J.;
RT "Bombolitins, a new class of mast cell degranulating peptides from the
RT venom of the bumblebee Megabombus pennsylvanicus.";
RL J. Biol. Chem. 260:1437-1444(1985).
CC -!- FUNCTION: Mast cell degranulating peptide.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- SIMILARITY: Belongs to the MCD family. Bombolitin subfamily.
CC {ECO:0000305}.
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DR PIR; D22595; D22595.
DR AlphaFoldDB; P07495; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
DR InterPro; IPR012534; Bombolitin.
DR Pfam; PF08096; Bombolitin; 1.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Mast cell degranulation; Secreted.
FT PEPTIDE 1..17
FT /note="Bombolitin-4"
FT /id="PRO_0000044041"
FT MOD_RES 17
FT /note="Valine amide"
FT /evidence="ECO:0000269|PubMed:2578459"
SQ SEQUENCE 17 AA; 1873 MW; A34A43514BCFDFB6 CRC64;
INIKDILAKL VKVLGHV