ID   BOL5_BOMPE              Reviewed;          17 AA.
AC   P07496;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Bombolitin-5;
DE   AltName: Full=Bombolitin V;
OS   Bombus pensylvanicus (American bumblebee) (Apis pensylvanica).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Bombus; Fervidobombus.
OX   NCBI_TaxID=28643;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT LEU-17.
RC   TISSUE=Venom;
RX   PubMed=2578459; DOI=10.1016/s0021-9258(18)89611-9;
RA   Argiolas A., Pisano J.J.;
RT   "Bombolitins, a new class of mast cell degranulating peptides from the
RT   venom of the bumblebee Megabombus pennsylvanicus.";
RL   J. Biol. Chem. 260:1437-1444(1985).
CC   -!- FUNCTION: Mast cell degranulating peptide.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the MCD family. Bombolitin subfamily.
CC       {ECO:0000305}.
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DR   PIR; E22595; E22595.
DR   AlphaFoldDB; P07496; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Mast cell degranulation; Secreted.
FT   PEPTIDE         1..17
FT                   /note="Bombolitin-5"
FT                   /id="PRO_0000044042"
FT   MOD_RES         17
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:2578459"
SQ   SEQUENCE   17 AA;  1731 MW;  B076C091571606A5 CRC64;
     INVLGILGLL GKALSHL