BOL7_BOMLA
ID BOL7_BOMLA Reviewed; 19 AA.
AC P0CD68;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 09-FEB-2010, sequence version 1.
DT 25-MAY-2022, entry version 16.
DE RecName: Full=Bombolitin-7;
OS Bombus lapidarius (Red-tailed bumblebee) (Apis lapidaria).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC Bombus; Melanobombus.
OX NCBI_TaxID=30192;
RN [1]
RP PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MASS
RP SPECTROMETRY.
RC TISSUE=Venom;
RX PubMed=16626777; DOI=10.1016/j.toxicon.2006.01.020;
RA Favreau P., Menin L., Michalet S., Perret F., Cheneval O., Stocklin M.,
RA Bulet P., Stocklin R.;
RT "Mass spectrometry strategies for venom mapping and peptide sequencing from
RT crude venoms: case applications with single arthropod specimen.";
RL Toxicon 47:676-687(2006).
CC -!- FUNCTION: Mast cell degranulating peptide. May also display
CC antibacterial and antifungal activities (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16626777}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000269|PubMed:16626777}.
CC -!- MASS SPECTROMETRY: Mass=2146.30; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:16626777};
CC -!- SIMILARITY: Belongs to the MCD family. Bombolitin subfamily.
CC {ECO:0000305}.
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DR AlphaFoldDB; P0CD68; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide;
KW Mast cell degranulation; Secreted; Toxin.
FT PEPTIDE 1..19
FT /note="Bombolitin-7"
FT /id="PRO_0000391362"
SQ SEQUENCE 19 AA; 2174 MW; 40C967AB7091594E CRC64;
LKLKDILGKI KVILSHLNK