ID   BOL8_BOMLA              Reviewed;          19 AA.
AC   P0CD69;
DT   09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Bombolitin-8;
OS   Bombus lapidarius (Red-tailed bumblebee) (Apis lapidaria).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Bombus; Melanobombus.
OX   NCBI_TaxID=30192;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=16626777; DOI=10.1016/j.toxicon.2006.01.020;
RA   Favreau P., Menin L., Michalet S., Perret F., Cheneval O., Stocklin M.,
RA   Bulet P., Stocklin R.;
RT   "Mass spectrometry strategies for venom mapping and peptide sequencing from
RT   crude venoms: case applications with single arthropod specimen.";
RL   Toxicon 47:676-687(2006).
CC   -!- FUNCTION: Mast cell degranulating peptide. May also display
CC       antibacterial and antifungal activities (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16626777}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:16626777}.
CC   -!- MASS SPECTROMETRY: Mass=2073.34; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:16626777};
CC   -!- SIMILARITY: Belongs to the MCD family. Bombolitin subfamily.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P0CD69; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide;
KW   Mast cell degranulation; Secreted; Toxin.
FT   PEPTIDE         1..19
FT                   /note="Bombolitin-8"
FT                   /id="PRO_0000391363"
SQ   SEQUENCE   19 AA;  2075 MW;  4FF136AB70914BC5 CRC64;
     LKLKSILGKL GVILSHLNK