SYT13_HUMAN
ID SYT13_HUMAN Reviewed; 426 AA.
AC Q7L8C5; A8K4P4; D3DQP1; Q9BQS3; Q9H041; Q9P2C0;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Synaptotagmin-13;
DE AltName: Full=Synaptotagmin XIII;
DE Short=SytXIII;
GN Name=SYT13; Synonyms=KIAA1427;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVI. The
RT complete sequences of 150 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:65-73(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 150-322, AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=11543631; DOI=10.1006/geno.2001.6619;
RA Craxton M.A.;
RT "Genomic analysis of synaptotagmin genes.";
RL Genomics 77:43-49(2001).
RN [7]
RP STRUCTURE BY NMR OF 155-280.
RG RIKEN structural genomics initiative (RSGI);
RT "The first C2 domain of human synaptotagmin XIII.";
RL Submitted (NOV-2004) to the PDB data bank.
CC -!- FUNCTION: May be involved in transport vesicle docking to the plasma
CC membrane. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with NRXN1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in brain, pancreas and kidney.
CC {ECO:0000269|PubMed:11543631}.
CC -!- DOMAIN: The first C2 domain/C2A does not mediate Ca(2+)-dependent
CC phospholipid binding. {ECO:0000250}.
CC -!- DOMAIN: The second C2 domain/C2B domain binds phospholipids regardless
CC of whether calcium is present. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the synaptotagmin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA92665.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB037848; BAA92665.1; ALT_INIT; mRNA.
DR EMBL; AK291009; BAF83698.1; -; mRNA.
DR EMBL; AL512743; CAC21669.1; -; mRNA.
DR EMBL; CH471064; EAW68043.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68044.1; -; Genomic_DNA.
DR EMBL; BC093830; AAH93830.1; -; mRNA.
DR EMBL; BC093832; AAH93832.1; -; mRNA.
DR EMBL; AJ303362; CAC33884.1; -; mRNA.
DR CCDS; CCDS31470.1; -.
DR RefSeq; NP_065877.1; NM_020826.2.
DR PDB; 1WFM; NMR; -; A=155-279.
DR PDBsum; 1WFM; -.
DR AlphaFoldDB; Q7L8C5; -.
DR SMR; Q7L8C5; -.
DR BioGRID; 121638; 7.
DR IntAct; Q7L8C5; 1.
DR STRING; 9606.ENSP00000020926; -.
DR GlyGen; Q7L8C5; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q7L8C5; -.
DR PhosphoSitePlus; Q7L8C5; -.
DR BioMuta; SYT13; -.
DR DMDM; 74749900; -.
DR MassIVE; Q7L8C5; -.
DR PaxDb; Q7L8C5; -.
DR PeptideAtlas; Q7L8C5; -.
DR PRIDE; Q7L8C5; -.
DR ProteomicsDB; 68836; -.
DR Antibodypedia; 42821; 137 antibodies from 29 providers.
DR DNASU; 57586; -.
DR Ensembl; ENST00000020926.8; ENSP00000020926.3; ENSG00000019505.8.
DR GeneID; 57586; -.
DR KEGG; hsa:57586; -.
DR MANE-Select; ENST00000020926.8; ENSP00000020926.3; NM_020826.3; NP_065877.1.
DR UCSC; uc001myq.3; human.
DR CTD; 57586; -.
DR DisGeNET; 57586; -.
DR GeneCards; SYT13; -.
DR HGNC; HGNC:14962; SYT13.
DR HPA; ENSG00000019505; Tissue enhanced (brain, gallbladder, pituitary gland).
DR MIM; 607716; gene.
DR neXtProt; NX_Q7L8C5; -.
DR OpenTargets; ENSG00000019505; -.
DR PharmGKB; PA37942; -.
DR VEuPathDB; HostDB:ENSG00000019505; -.
DR eggNOG; KOG1028; Eukaryota.
DR GeneTree; ENSGT00940000160226; -.
DR HOGENOM; CLU_023008_2_0_1; -.
DR InParanoid; Q7L8C5; -.
DR OMA; CDCYIQG; -.
DR OrthoDB; 925064at2759; -.
DR PhylomeDB; Q7L8C5; -.
DR TreeFam; TF315600; -.
DR PathwayCommons; Q7L8C5; -.
DR SignaLink; Q7L8C5; -.
DR BioGRID-ORCS; 57586; 6 hits in 1066 CRISPR screens.
DR ChiTaRS; SYT13; human.
DR EvolutionaryTrace; Q7L8C5; -.
DR GeneWiki; SYT13; -.
DR GenomeRNAi; 57586; -.
DR Pharos; Q7L8C5; Tbio.
DR PRO; PR:Q7L8C5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q7L8C5; protein.
DR Bgee; ENSG00000019505; Expressed in middle temporal gyrus and 119 other tissues.
DR ExpressionAtlas; Q7L8C5; baseline and differential.
DR Genevisible; Q7L8C5; HS.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0070382; C:exocytic vesicle; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0030133; C:transport vesicle; IDA:LIFEdb.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0005544; F:calcium-dependent phospholipid binding; IBA:GO_Central.
DR GO; GO:0030276; F:clathrin binding; IBA:GO_Central.
DR GO; GO:0001786; F:phosphatidylserine binding; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0017156; P:calcium-ion regulated exocytosis; IBA:GO_Central.
DR GO; GO:0071277; P:cellular response to calcium ion; IBA:GO_Central.
DR GO; GO:0017158; P:regulation of calcium ion-dependent exocytosis; IBA:GO_Central.
DR GO; GO:0014059; P:regulation of dopamine secretion; IBA:GO_Central.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 2.60.40.150; -; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR028692; SYT13.
DR PANTHER; PTHR10024:SF250; PTHR10024:SF250; 1.
DR Pfam; PF00168; C2; 2.
DR SMART; SM00239; C2; 1.
DR SUPFAM; SSF49562; SSF49562; 2.
DR PROSITE; PS50004; C2; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..426
FT /note="Synaptotagmin-13"
FT /id="PRO_0000183975"
FT TOPO_DOM 1..6
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..426
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 158..275
FT /note="C2 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 287..422
FT /note="C2 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT STRAND 161..168
FT /evidence="ECO:0007829|PDB:1WFM"
FT TURN 170..172
FT /evidence="ECO:0007829|PDB:1WFM"
FT STRAND 174..183
FT /evidence="ECO:0007829|PDB:1WFM"
FT STRAND 193..201
FT /evidence="ECO:0007829|PDB:1WFM"
FT STRAND 204..209
FT /evidence="ECO:0007829|PDB:1WFM"
FT STRAND 217..220
FT /evidence="ECO:0007829|PDB:1WFM"
FT STRAND 225..228
FT /evidence="ECO:0007829|PDB:1WFM"
FT STRAND 238..245
FT /evidence="ECO:0007829|PDB:1WFM"
FT STRAND 255..267
FT /evidence="ECO:0007829|PDB:1WFM"
FT STRAND 273..276
FT /evidence="ECO:0007829|PDB:1WFM"
SQ SEQUENCE 426 AA; 46885 MW; 9BD0AD533E0CE886 CRC64;
MVLSVPVIAL GATLGTATSI LALCGVTCLC RHMHPKKGLL PRDQDPDLEK AKPSLLGSAQ
QFNVKKSTEP VQPRALLKFP DIYGPRPAVT APEVINYADY SLRSTEEPTA PASPQPPNDS
RLKRQVTEEL FILPQNGVVE DVCVMETWNP EKAASWNQAP KLHYCLDYDC QKAELFVTRL
EAVTSNHDGG CDCYVQGSVA NRTGSVEAQT ALKKRQLHTT WEEGLVLPLA EEELPTATLT
LTLRTCDRFS RHSVAGELRL GLDGTSVPLG AAQWGELKTS AKEPSAGAGE VLLSISYLPA
ANRLLVVLIK AKNLHSNQSK ELLGKDVSVK VTLKHQARKL KKKQTKRAKH KINPVWNEMI
MFELPDDLLQ ASSVELEVLG QDDSGQSCAL GHCSLGLHTS GSERSHWEEM LKNPRRQIAM
WHQLHL
