SYT16_HUMAN
ID SYT16_HUMAN Reviewed; 645 AA.
AC Q17RD7; B4DZH2; B7ZL60; C9J8I3; Q707N2; Q7Z441; Q8IUU0; Q9BQR8;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Synaptotagmin-16;
DE AltName: Full=Chr14Syt;
DE AltName: Full=Synaptotagmin 14-like protein;
DE AltName: Full=Synaptotagmin XIV-related protein;
GN Name=SYT16; Synonyms=STREP14, SYT14L, SYT14R;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=12801916; DOI=10.1093/jb/mvg082;
RA Fukuda M.;
RT "Molecular cloning, expression, and characterization of a novel class of
RT synaptotagmin (Syt XIV) conserved from Drosophila to humans.";
RL J. Biochem. 133:641-649(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT LEU-131.
RX PubMed=15238157; DOI=10.1186/1471-2164-5-43;
RA Craxton M.A.;
RT "Synaptotagmin gene content of the sequenced genomes.";
RL BMC Genomics 5:43-43(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT
RP ALA-10.
RC TISSUE=Brain cortex;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 551-645, AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=11543631; DOI=10.1006/geno.2001.6619;
RA Craxton M.A.;
RT "Genomic analysis of synaptotagmin genes.";
RL Genomics 77:43-49(2001).
CC -!- FUNCTION: May be involved in the trafficking and exocytosis of
CC secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.
CC -!- SUBUNIT: Homodimer. Can also form heterodimers (By similarity).
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q17RD7; Q6RW13: AGTRAP; NbExp=5; IntAct=EBI-10238936, EBI-741181;
CC Q17RD7; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-10238936, EBI-11522760;
CC Q17RD7; P02654: APOC1; NbExp=3; IntAct=EBI-10238936, EBI-1220105;
CC Q17RD7; P55056: APOC4; NbExp=3; IntAct=EBI-10238936, EBI-18302142;
CC Q17RD7; Q8IYJ2-2: C10orf67; NbExp=3; IntAct=EBI-10238936, EBI-13381098;
CC Q17RD7; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-10238936, EBI-11522780;
CC Q17RD7; Q9H1C7: CYSTM1; NbExp=3; IntAct=EBI-10238936, EBI-12867082;
CC Q17RD7; Q96Q80: DERL3; NbExp=3; IntAct=EBI-10238936, EBI-12831318;
CC Q17RD7; Q92915-2: FGF14; NbExp=3; IntAct=EBI-10238936, EBI-12836320;
CC Q17RD7; Q2KHT4-3: GSG1; NbExp=3; IntAct=EBI-10238936, EBI-12951679;
CC Q17RD7; A8MV81: HIGD1C; NbExp=3; IntAct=EBI-10238936, EBI-12809676;
CC Q17RD7; P13473-2: LAMP2; NbExp=3; IntAct=EBI-10238936, EBI-21591415;
CC Q17RD7; Q96B96: LDAF1; NbExp=3; IntAct=EBI-10238936, EBI-7055862;
CC Q17RD7; O95563: MPC2; NbExp=3; IntAct=EBI-10238936, EBI-719403;
CC Q17RD7; Q15390: MTFR1; NbExp=3; IntAct=EBI-10238936, EBI-724207;
CC Q17RD7; Q8IXK0: PHC2; NbExp=3; IntAct=EBI-10238936, EBI-713786;
CC Q17RD7; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-10238936, EBI-742388;
CC Q17RD7; Q9UI14: RABAC1; NbExp=8; IntAct=EBI-10238936, EBI-712367;
CC Q17RD7; Q96HR9-2: REEP6; NbExp=3; IntAct=EBI-10238936, EBI-14065960;
CC Q17RD7; O15258: RER1; NbExp=3; IntAct=EBI-10238936, EBI-716910;
CC Q17RD7; Q6NTF9-3: RHBDD2; NbExp=3; IntAct=EBI-10238936, EBI-17589229;
CC Q17RD7; Q9NS64: RPRM; NbExp=3; IntAct=EBI-10238936, EBI-1052363;
CC Q17RD7; Q9NQC3: RTN4; NbExp=5; IntAct=EBI-10238936, EBI-715945;
CC Q17RD7; Q8N3Y7: SDR16C5; NbExp=3; IntAct=EBI-10238936, EBI-3923480;
CC Q17RD7; Q8WV19: SFT2D1; NbExp=3; IntAct=EBI-10238936, EBI-2854842;
CC Q17RD7; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-10238936, EBI-2623095;
CC Q17RD7; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-10238936, EBI-11528917;
CC Q17RD7; Q9NYZ1: TVP23B; NbExp=3; IntAct=EBI-10238936, EBI-11343401;
CC Q17RD7; O43829: ZBTB14; NbExp=3; IntAct=EBI-10238936, EBI-10176632;
CC Q17RD7-3; P28799: GRN; NbExp=3; IntAct=EBI-25861603, EBI-747754;
CC Q17RD7-3; P04792: HSPB1; NbExp=3; IntAct=EBI-25861603, EBI-352682;
CC Q17RD7-3; O60333-2: KIF1B; NbExp=3; IntAct=EBI-25861603, EBI-10975473;
CC Q17RD7-3; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-25861603, EBI-396669;
CC Q17RD7-3; O76024: WFS1; NbExp=3; IntAct=EBI-25861603, EBI-720609;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q17RD7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q17RD7-2; Sequence=VSP_021379;
CC Name=3;
CC IsoId=Q17RD7-3; Sequence=VSP_021378;
CC Name=4;
CC IsoId=Q17RD7-4; Sequence=VSP_057225, VSP_057226;
CC -!- TISSUE SPECIFICITY: Expressed in brain. {ECO:0000269|PubMed:11543631}.
CC -!- SIMILARITY: Belongs to the synaptotagmin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAE85114.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB102949; BAC76810.1; -; mRNA.
DR EMBL; AJ617628; CAE85114.1; ALT_SEQ; mRNA.
DR EMBL; AK302919; BAG64084.1; -; mRNA.
DR EMBL; AL356018; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL390816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC040924; AAH40924.1; -; mRNA.
DR EMBL; BC117363; AAI17364.1; -; mRNA.
DR EMBL; BC143598; AAI43599.1; -; mRNA.
DR EMBL; AJ303367; CAC33889.1; -; mRNA.
DR CCDS; CCDS45121.1; -. [Q17RD7-1]
DR RefSeq; NP_114120.2; NM_031914.2.
DR RefSeq; XP_006720335.1; XM_006720272.3. [Q17RD7-1]
DR RefSeq; XP_011535521.1; XM_011537219.1.
DR RefSeq; XP_016877182.1; XM_017021693.1.
DR RefSeq; XP_016877183.1; XM_017021694.1.
DR RefSeq; XP_016877184.1; XM_017021695.1.
DR AlphaFoldDB; Q17RD7; -.
DR SMR; Q17RD7; -.
DR BioGRID; 123767; 41.
DR IntAct; Q17RD7; 43.
DR MINT; Q17RD7; -.
DR STRING; 9606.ENSP00000478637; -.
DR iPTMnet; Q17RD7; -.
DR PhosphoSitePlus; Q17RD7; -.
DR BioMuta; SYT16; -.
DR DMDM; 313104017; -.
DR MassIVE; Q17RD7; -.
DR PaxDb; Q17RD7; -.
DR PeptideAtlas; Q17RD7; -.
DR PRIDE; Q17RD7; -.
DR ProteomicsDB; 5599; -.
DR ProteomicsDB; 61148; -. [Q17RD7-1]
DR ProteomicsDB; 61149; -. [Q17RD7-2]
DR ProteomicsDB; 61150; -. [Q17RD7-3]
DR Antibodypedia; 60; 132 antibodies from 22 providers.
DR DNASU; 83851; -.
DR Ensembl; ENST00000555409.1; ENSP00000451035.1; ENSG00000139973.18. [Q17RD7-4]
DR Ensembl; ENST00000568344.5; ENSP00000478637.1; ENSG00000139973.18. [Q17RD7-1]
DR Ensembl; ENST00000683842.1; ENSP00000508274.1; ENSG00000139973.18. [Q17RD7-1]
DR GeneID; 83851; -.
DR MANE-Select; ENST00000683842.1; ENSP00000508274.1; NM_001367656.1; NP_001354585.1.
DR UCSC; uc001xfu.2; human. [Q17RD7-1]
DR CTD; 83851; -.
DR DisGeNET; 83851; -.
DR GeneCards; SYT16; -.
DR HGNC; HGNC:23142; SYT16.
DR HPA; ENSG00000139973; Group enriched (brain, testis).
DR MIM; 610950; gene.
DR neXtProt; NX_Q17RD7; -.
DR OpenTargets; ENSG00000139973; -.
DR PharmGKB; PA134964250; -.
DR VEuPathDB; HostDB:ENSG00000139973; -.
DR eggNOG; KOG1028; Eukaryota.
DR GeneTree; ENSGT00940000159673; -.
DR HOGENOM; CLU_023008_6_1_1; -.
DR InParanoid; Q17RD7; -.
DR OMA; QWPNQTL; -.
DR OrthoDB; 780532at2759; -.
DR PhylomeDB; Q17RD7; -.
DR TreeFam; TF351132; -.
DR PathwayCommons; Q17RD7; -.
DR SignaLink; Q17RD7; -.
DR BioGRID-ORCS; 83851; 7 hits in 1071 CRISPR screens.
DR ChiTaRS; SYT16; human.
DR GenomeRNAi; 83851; -.
DR Pharos; Q17RD7; Tbio.
DR PRO; PR:Q17RD7; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q17RD7; protein.
DR Bgee; ENSG00000139973; Expressed in Brodmann (1909) area 23 and 94 other tissues.
DR ExpressionAtlas; Q17RD7; baseline and differential.
DR Genevisible; Q17RD7; HS.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IEA:InterPro.
DR Gene3D; 2.60.40.150; -; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR043541; SYT14/14L/16.
DR InterPro; IPR028690; SYT16.
DR PANTHER; PTHR46129; PTHR46129; 1.
DR PANTHER; PTHR46129:SF4; PTHR46129:SF4; 1.
DR Pfam; PF00168; C2; 2.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; SSF49562; 2.
DR PROSITE; PS50004; C2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..645
FT /note="Synaptotagmin-16"
FT /id="PRO_0000258584"
FT DOMAIN 350..469
FT /note="C2 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 505..640
FT /note="C2 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT REGION 102..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..442
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021378"
FT VAR_SEQ 312..331
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12801916"
FT /id="VSP_021379"
FT VAR_SEQ 332..383
FT /note="EQDRTNLQVPSGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRS
FT -> ANLNLKRKGYLLDVYCLSSPLLFTTSLHRRNRTGPICRCHPGSQSPSQSVVT (in
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_057225"
FT VAR_SEQ 384..645
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_057226"
FT VARIANT 10
FT /note="V -> A (in dbSNP:rs8019076)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_028930"
FT VARIANT 131
FT /note="R -> L (in dbSNP:rs17099370)"
FT /evidence="ECO:0000269|PubMed:15238157"
FT /id="VAR_028931"
FT CONFLICT 175
FT /note="V -> I (in Ref. 1; BAC76810)"
FT /evidence="ECO:0000305"
FT CONFLICT 517
FT /note="A -> V (in Ref. 2; CAE85114)"
FT /evidence="ECO:0000305"
FT CONFLICT 614
FT /note="Q -> L (in Ref. 2; CAE85114)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 645 AA; 72274 MW; A9E11164542AAAAE CRC64;
MVLAMASQDV QNFFQPFSSW ISRVYEALQQ AGDMLSASLV NISKQDSKLS DKLDQDLDNI
QIQETYFEDE EQDNDWSQED ANSLFLEVDH FSCCNSDLQD SAQNSSPSLS QHAKDSCSTM
SQWPNWASDD RKLPHVLSSI AEEEHHLEKQ RSGLQHGFDS QLPGTLETVN GKKQVNSFGD
DEELSTSSDS DEEVIKQFEI SVSRSQSFRS VTSEKGKQTG LEQKPKFSRS LLTHGEDGTE
VSACEDLDGA SQRRYSENLS YGEDDHIPAH SQSPCERGDA KHHGTSHQES SVVQSLRRQS
TEGSLEMETA FNSRGFEDSY ATDSSSMWSP EEQDRTNLQV PSGVSEPISK CGDLDVIFEY
RAASQKLTVT IVRAQGLPDK DRSGVNSWQV HVVLLPGKKH RGRTNIQRGP NPVFREKVTF
AKLEPRDVAA CAVRFRLYAA RKMTRERMMG EKLFYLSHLH PEGEMKVTLV LEPRSNISSG
GSPLSPSAVS HSDSTSSTQS LSHGGAPELL VGLSYNATTG RLSVEMIKGS HFRNLAVNRA
PDTYGKLFLL NSVGQEMSRC KTSIRRGQPN PVYKETFVFQ VALFQLSDVT LMISVYNRRT
MKRKEMIGWI ALGQNSSGEE EQDHWEEMKE TKGQQICRWH TLLES
