SYT16_MOUSE
ID SYT16_MOUSE Reviewed; 639 AA.
AC Q7TN83; Q3UVM4; Q6PGM6; Q8BJ41;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Synaptotagmin-16;
DE AltName: Full=Synaptotagmin 14-like protein;
DE AltName: Full=Synaptotagmin XIV-related protein;
GN Name=Syt16; Synonyms=Strep14, Syt14l, Syt14r;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, TISSUE
RP SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=BALB/cJ;
RX PubMed=12801916; DOI=10.1093/jb/mvg082;
RA Fukuda M.;
RT "Molecular cloning, expression, and characterization of a novel class of
RT synaptotagmin (Syt XIV) conserved from Drosophila to humans.";
RL J. Biochem. 133:641-649(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in the trafficking and exocytosis of
CC secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.
CC {ECO:0000269|PubMed:12801916}.
CC -!- SUBUNIT: Homodimer. Can also form heterodimers.
CC {ECO:0000269|PubMed:12801916}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q7TN83-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7TN83-2; Sequence=VSP_021382, VSP_021384, VSP_021385;
CC Name=3;
CC IsoId=Q7TN83-3; Sequence=VSP_021381, VSP_021383;
CC -!- TISSUE SPECIFICITY: Highly expressed in heart and testis. Moderately
CC expressed in kidney. {ECO:0000269|PubMed:12801916}.
CC -!- DEVELOPMENTAL STAGE: Weakly expressed at 7 dpc and remains constant
CC from 11 dpc to 17 dpc. {ECO:0000269|PubMed:12801916}.
CC -!- SIMILARITY: Belongs to the synaptotagmin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC27947.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB102950; BAC76811.1; -; mRNA.
DR EMBL; AK032606; BAC27947.1; ALT_FRAME; mRNA.
DR EMBL; AK137129; BAE23245.1; -; mRNA.
DR EMBL; BC056932; AAH56932.1; -; mRNA.
DR CCDS; CCDS49089.1; -. [Q7TN83-2]
DR CCDS; CCDS88352.1; -. [Q7TN83-1]
DR RefSeq; NP_766392.2; NM_172804.2. [Q7TN83-2]
DR RefSeq; XP_006515903.1; XM_006515840.3.
DR AlphaFoldDB; Q7TN83; -.
DR SMR; Q7TN83; -.
DR BioGRID; 231962; 2.
DR STRING; 10090.ENSMUSP00000106081; -.
DR iPTMnet; Q7TN83; -.
DR PhosphoSitePlus; Q7TN83; -.
DR PeptideAtlas; Q7TN83; -.
DR PRIDE; Q7TN83; -.
DR ProteomicsDB; 254794; -. [Q7TN83-1]
DR ProteomicsDB; 254795; -. [Q7TN83-2]
DR ProteomicsDB; 254796; -. [Q7TN83-3]
DR Antibodypedia; 60; 132 antibodies from 22 providers.
DR DNASU; 238266; -.
DR Ensembl; ENSMUST00000221220; ENSMUSP00000152623; ENSMUSG00000044912. [Q7TN83-2]
DR Ensembl; ENSMUST00000238790; ENSMUSP00000158983; ENSMUSG00000044912. [Q7TN83-1]
DR GeneID; 238266; -.
DR KEGG; mmu:238266; -.
DR UCSC; uc007nwu.1; mouse. [Q7TN83-2]
DR UCSC; uc007nwv.1; mouse. [Q7TN83-1]
DR CTD; 83851; -.
DR MGI; MGI:2673872; Syt16.
DR VEuPathDB; HostDB:ENSMUSG00000044912; -.
DR eggNOG; KOG1028; Eukaryota.
DR GeneTree; ENSGT00940000159673; -.
DR HOGENOM; CLU_023008_6_1_1; -.
DR InParanoid; Q7TN83; -.
DR OMA; QWPNQTL; -.
DR OrthoDB; 780532at2759; -.
DR PhylomeDB; Q7TN83; -.
DR TreeFam; TF351132; -.
DR BioGRID-ORCS; 238266; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Syt16; mouse.
DR PRO; PR:Q7TN83; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q7TN83; protein.
DR Bgee; ENSMUSG00000044912; Expressed in amygdala and 127 other tissues.
DR ExpressionAtlas; Q7TN83; baseline and differential.
DR Genevisible; Q7TN83; MM.
DR GO; GO:0016021; C:integral component of membrane; ISS:MGI.
DR GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR GO; GO:0005543; F:phospholipid binding; IDA:MGI.
DR GO; GO:0006887; P:exocytosis; IEA:InterPro.
DR Gene3D; 2.60.40.150; -; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR043541; SYT14/14L/16.
DR InterPro; IPR028690; SYT16.
DR PANTHER; PTHR46129; PTHR46129; 1.
DR PANTHER; PTHR46129:SF4; PTHR46129:SF4; 1.
DR Pfam; PF00168; C2; 2.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; SSF49562; 2.
DR PROSITE; PS50004; C2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..639
FT /note="Synaptotagmin-16"
FT /id="PRO_0000258585"
FT DOMAIN 344..463
FT /note="C2 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 499..634
FT /note="C2 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT REGION 95..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..152
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021381"
FT VAR_SEQ 1..105
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021382"
FT VAR_SEQ 106..169
FT /note="SPTLGQQAEDSSSVIPPWPSKIPGAPKPQPVLSSIAEEDHHSERQRCGRQHG
FT SGTLEKVNGRKQ -> MATDITPEAIGFLSAIGVFVVLLAVLLLFINKKLCSENLRGHP
FT YPEQRGKRKHSRDKTGGHTGT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021384"
FT VAR_SEQ 153..169
FT /note="GRQHGSGTLEKVNGRKQ -> MTSKEGGGEGEEIIHN (in isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021383"
FT VAR_SEQ 240
FT /note="E -> EGIHCSALHCRQGQVN (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021385"
FT CONFLICT 111
FT /note="Q -> K (in Ref. 2; BAC27947)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 639 AA; 71255 MW; F439F2D1009C556A CRC64;
MVLTMASQDV QNFFQPLSSW LSRVYEALQQ AGDALSASLV LLSKHDSALS DKPEQDLDAA
QIQQTYLEDE EQDHDGSPEE ASSLFLEEDH FSLSNSDLQD SVQTASPTLG QQAEDSSSVI
PPWPSKIPGA PKPQPVLSSI AEEDHHSERQ RCGRQHGSGT LEKVNGRKQV NSFGDDEEPS
TSSESDEDVT KQFKISVSRS QSFRSGVSEK GKTTELEQKI KCKRLLCTHQ EDSAEGSACE
DLDRTSQLSY SEILSYEDRP ISILPQSPFE SRNVRHHGPC RPEMGMVRSL GRPCADGVLE
TETAFVSRGF EDSYATHSSS LWSPEEQDGT SLQVPHRLLE PISKCGDLDV IFEYRAVTQK
LTVTIVRAQG LPDKDRSGVN SWQVHIVLLP SKKQRGKTNI QRGPNPVFKE KVTFTKLEPR
DVASCAVRFR LYAARKMTRE RMMGEKLFCL SHLHPEGEMK VTLVLEPRSN LSSGESPLSP
SVVSHSDSAS STQSLSHGGV PELLVGLSYN ATTGRLSVEM IKGSHFRNLA ANRAPDTYGK
LFLLNCVGQE MSRCKTSIRR GQPNPVYKET FVFQVALFQL SDVTLMISIY SRRTMKRKEM
IGWVALGQNS SGEEEQEHWE EMKESKGQQT CRWHTLLES
