BOLA1_MOUSE
ID BOLA1_MOUSE Reviewed; 137 AA.
AC Q9D8S9;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=BolA-like protein 1;
GN Name=Bola1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP STRUCTURE BY NMR OF 13-128.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of Bola1 protein from Mus musculus.";
RL Submitted (NOV-2003) to the PDB data bank.
CC -!- FUNCTION: Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly
CC factor that facilitates (Fe-S) cluster insertion into a subset of
CC mitochondrial proteins (By similarity). Probably acts together with the
CC monothiol glutaredoxin GLRX5. May protect cells against oxidative
CC stress (By similarity). {ECO:0000250|UniProtKB:Q3E793,
CC ECO:0000250|UniProtKB:Q9Y3E2}.
CC -!- SUBUNIT: Interacts with GLRX5. {ECO:0000250|UniProtKB:Q9Y3E2}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9Y3E2}.
CC -!- SIMILARITY: Belongs to the BolA/IbaG family. {ECO:0000305}.
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DR EMBL; AK007718; BAB25210.1; -; mRNA.
DR EMBL; BC027558; AAH27558.1; -; mRNA.
DR CCDS; CCDS17632.1; -.
DR RefSeq; NP_081251.1; NM_026975.2.
DR RefSeq; XP_006502075.1; XM_006502012.1.
DR PDB; 1V60; NMR; -; A=13-128.
DR PDBsum; 1V60; -.
DR AlphaFoldDB; Q9D8S9; -.
DR SMR; Q9D8S9; -.
DR BioGRID; 213267; 2.
DR STRING; 10090.ENSMUSP00000102716; -.
DR iPTMnet; Q9D8S9; -.
DR PhosphoSitePlus; Q9D8S9; -.
DR CPTAC; non-CPTAC-3769; -.
DR EPD; Q9D8S9; -.
DR jPOST; Q9D8S9; -.
DR MaxQB; Q9D8S9; -.
DR PaxDb; Q9D8S9; -.
DR PeptideAtlas; Q9D8S9; -.
DR PRIDE; Q9D8S9; -.
DR ProteomicsDB; 273834; -.
DR Antibodypedia; 1825; 181 antibodies from 26 providers.
DR Ensembl; ENSMUST00000016087; ENSMUSP00000016087; ENSMUSG00000015943.
DR Ensembl; ENSMUST00000107099; ENSMUSP00000102716; ENSMUSG00000015943.
DR Ensembl; ENSMUST00000177442; ENSMUSP00000134765; ENSMUSG00000015943.
DR GeneID; 69168; -.
DR KEGG; mmu:69168; -.
DR UCSC; uc008qmg.2; mouse.
DR CTD; 51027; -.
DR MGI; MGI:1916418; Bola1.
DR VEuPathDB; HostDB:ENSMUSG00000015943; -.
DR eggNOG; KOG2313; Eukaryota.
DR GeneTree; ENSGT00510000048165; -.
DR HOGENOM; CLU_109462_3_0_1; -.
DR InParanoid; Q9D8S9; -.
DR OMA; CLGGFGK; -.
DR OrthoDB; 1603661at2759; -.
DR PhylomeDB; Q9D8S9; -.
DR TreeFam; TF354266; -.
DR BioGRID-ORCS; 69168; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Bola1; mouse.
DR EvolutionaryTrace; Q9D8S9; -.
DR PRO; PR:Q9D8S9; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9D8S9; protein.
DR Bgee; ENSMUSG00000015943; Expressed in right kidney and 159 other tissues.
DR Genevisible; Q9D8S9; MM.
DR GO; GO:1990229; C:iron-sulfur cluster assembly complex; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR InterPro; IPR002634; BolA.
DR InterPro; IPR036065; BolA-like_sf.
DR Pfam; PF01722; BolA; 1.
DR PIRSF; PIRSF003113; BolA; 1.
DR SUPFAM; SSF82657; SSF82657; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Mitochondrion; Phosphoprotein; Reference proteome.
FT CHAIN 1..137
FT /note="BolA-like protein 1"
FT /id="PRO_0000201234"
FT REGION 115..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 81
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT STRAND 27..29
FT /evidence="ECO:0007829|PDB:1V60"
FT HELIX 31..43
FT /evidence="ECO:0007829|PDB:1V60"
FT STRAND 47..53
FT /evidence="ECO:0007829|PDB:1V60"
FT STRAND 57..59
FT /evidence="ECO:0007829|PDB:1V60"
FT STRAND 66..73
FT /evidence="ECO:0007829|PDB:1V60"
FT HELIX 75..77
FT /evidence="ECO:0007829|PDB:1V60"
FT HELIX 82..92
FT /evidence="ECO:0007829|PDB:1V60"
FT HELIX 94..97
FT /evidence="ECO:0007829|PDB:1V60"
FT TURN 98..100
FT /evidence="ECO:0007829|PDB:1V60"
FT STRAND 102..109
FT /evidence="ECO:0007829|PDB:1V60"
FT TURN 111..116
FT /evidence="ECO:0007829|PDB:1V60"
SQ SEQUENCE 137 AA; 14379 MW; EC5B187A3C597155 CRC64;
MLSARSAQCM VSMATRSCVS RGSAGSAAAG PVEAAIRAKL EQALSPEVLE LRNESGGHAV
PAGSETHFRV AVVSSRFEGM SPLQRHRLVH EALSEELAGP VHALAIQAKT PAQWRENPQL
DISPPCLGGS KKTRGTS
