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SYT5_RAT
ID   SYT5_RAT                Reviewed;         386 AA.
AC   P47861; Q56A28;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 167.
DE   RecName: Full=Synaptotagmin-5;
DE   AltName: Full=Synaptotagmin IX;
DE   AltName: Full=Synaptotagmin V;
DE            Short=SytV;
GN   Name=Syt5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RX   PubMed=7698322; DOI=10.1016/0014-5793(95)00176-a;
RA   Craxton M.A., Goedert M.;
RT   "Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brain.";
RL   FEBS Lett. 361:196-200(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7597049; DOI=10.1073/pnas.92.13.5895;
RA   Hudson A.W., Birnbaum M.J.;
RT   "Identification of a nonneuronal isoform of synaptotagmin.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:5895-5899(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH TUBULIN.
RX   PubMed=12966166; DOI=10.1242/jcs.00719;
RA   Haberman Y., Grimberg E., Fukuda M., Sagi-Eisenberg R.;
RT   "Synaptotagmin IX, a possible linker between the perinuclear endocytic
RT   recycling compartment and the microtubules.";
RL   J. Cell Sci. 116:4307-4318(2003).
CC   -!- FUNCTION: May be involved in Ca(2+)-dependent exocytosis of secretory
CC       vesicles through Ca(2+) and phospholipid binding to the C2 domain or
CC       may serve as Ca(2+) sensors in the process of vesicular trafficking and
CC       exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine
CC       in PC12 cells. Required for export from the endocytic recycling
CC       compartment to the cell surface. {ECO:0000269|PubMed:12966166}.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00041};
CC       Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2
CC       domains. {ECO:0000250|UniProtKB:O00445};
CC   -!- SUBUNIT: Homodimer (By similarity). Interacts with both alpha- and
CC       beta-tubulin (PubMed:12966166). {ECO:0000250,
CC       ECO:0000269|PubMed:12966166}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC       vesicle membrane {ECO:0000269|PubMed:12966166}; Single-pass membrane
CC       protein {ECO:0000269|PubMed:12966166}. Recycling endosome membrane
CC       {ECO:0000269|PubMed:12966166}; Single-pass membrane protein
CC       {ECO:0000269|PubMed:12966166}. Note=In mast cells, localizes to the
CC       endocytic recycling compartment.
CC   -!- TISSUE SPECIFICITY: Expressed in kidney, adipose tissue, lung and
CC       heart, as well as at higher levels in brain.
CC   -!- SIMILARITY: Belongs to the synaptotagmin family. {ECO:0000305}.
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DR   EMBL; X84884; CAA59311.1; -; mRNA.
DR   EMBL; U26402; AAA81382.1; -; mRNA.
DR   EMBL; BC092198; AAH92198.1; -; mRNA.
DR   PIR; I59387; I59387.
DR   RefSeq; NP_062223.1; NM_019350.2.
DR   RefSeq; XP_017445103.1; XM_017589614.1.
DR   RefSeq; XP_017445104.1; XM_017589615.1.
DR   AlphaFoldDB; P47861; -.
DR   SMR; P47861; -.
DR   BioGRID; 248527; 1.
DR   STRING; 10116.ENSRNOP00000024547; -.
DR   iPTMnet; P47861; -.
DR   PhosphoSitePlus; P47861; -.
DR   jPOST; P47861; -.
DR   PaxDb; P47861; -.
DR   PRIDE; P47861; -.
DR   Ensembl; ENSRNOT00000024547; ENSRNOP00000024547; ENSRNOG00000018217.
DR   GeneID; 54309; -.
DR   KEGG; rno:54309; -.
DR   UCSC; RGD:3806; rat.
DR   CTD; 6861; -.
DR   RGD; 3806; Syt5.
DR   eggNOG; KOG1028; Eukaryota.
DR   GeneTree; ENSGT00940000161816; -.
DR   HOGENOM; CLU_023008_0_1_1; -.
DR   InParanoid; P47861; -.
DR   OMA; CLCRKRC; -.
DR   OrthoDB; 925064at2759; -.
DR   PhylomeDB; P47861; -.
DR   TreeFam; TF315600; -.
DR   PRO; PR:P47861; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000018217; Expressed in frontal cortex and 17 other tissues.
DR   Genevisible; P47861; RN.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0031045; C:dense core granule; ISO:RGD.
DR   GO; GO:0070382; C:exocytic vesicle; IBA:GO_Central.
DR   GO; GO:0099066; C:integral component of neuronal dense core vesicle membrane; ISO:RGD.
DR   GO; GO:0043005; C:neuron projection; ISO:RGD.
DR   GO; GO:0043025; C:neuronal cell body; ISO:RGD.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:1990769; C:proximal neuron projection; ISO:RGD.
DR   GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IDA:BHF-UCL.
DR   GO; GO:0030276; F:clathrin binding; IDA:BHF-UCL.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISO:RGD.
DR   GO; GO:0001786; F:phosphatidylserine binding; ISO:RGD.
DR   GO; GO:0046982; F:protein heterodimerization activity; ISO:RGD.
DR   GO; GO:0000149; F:SNARE binding; ISO:RGD.
DR   GO; GO:0019905; F:syntaxin binding; IDA:BHF-UCL.
DR   GO; GO:0048791; P:calcium ion-regulated exocytosis of neurotransmitter; IBA:GO_Central.
DR   GO; GO:0017156; P:calcium-ion regulated exocytosis; IBA:GO_Central.
DR   GO; GO:0071277; P:cellular response to calcium ion; IBA:GO_Central.
DR   GO; GO:0017158; P:regulation of calcium ion-dependent exocytosis; ISO:RGD.
DR   GO; GO:0014059; P:regulation of dopamine secretion; IBA:GO_Central.
DR   GO; GO:0048488; P:synaptic vesicle endocytosis; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 2.60.40.150; -; 2.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR001565; Synaptotagmin.
DR   InterPro; IPR028689; SYT5.
DR   PANTHER; PTHR10024:SF282; PTHR10024:SF282; 1.
DR   Pfam; PF00168; C2; 2.
DR   PRINTS; PR00360; C2DOMAIN.
DR   PRINTS; PR00399; SYNAPTOTAGMN.
DR   SMART; SM00239; C2; 2.
DR   SUPFAM; SSF49562; SSF49562; 2.
DR   PROSITE; PS50004; C2; 2.
PE   1: Evidence at protein level;
KW   Calcium; Cytoplasmic vesicle; Endosome; Membrane; Metal-binding;
KW   Reference proteome; Repeat; Synapse; Transmembrane; Transmembrane helix.
FT   CHAIN           1..386
FT                   /note="Synaptotagmin-5"
FT                   /id="PRO_0000183953"
FT   TOPO_DOM        1..24
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        46..386
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          108..227
FT                   /note="C2 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   DOMAIN          239..372
FT                   /note="C2 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         138
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         139
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         139
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         145
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         197
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         197
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         198
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         199
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         199
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         199
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         202
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         205
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         205
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         270
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         276
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         330
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         332
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   VARIANT         182
FT                   /note="P -> S"
FT   VARIANT         237
FT                   /note="Missing"
SQ   SEQUENCE   386 AA;  43127 MW;  51B881ADD46E3FD6 CRC64;
     MFPEPPTPGS PAPETPPDSS RIRQGAVPAW VLATILLGSG LLVFSSCFCL YRKRCRRRMG
     KKSQAQAQVH LQEVKELGRS YIDKVQPEIE ELDPSPSMPG QQVLDKHQLG RLQYSLDYDF
     QTGQLLVGIL QAEGLAALDL GGSSDPYVSV YLLPDKRRRH ETKVHRQTLN PHFGETFAFK
     VPYVELGGRV LVMAVYDFDR FSRNDAIGEV RVPMSSVNLG RPVQAWRELQ VAPKEEQEKL
     GDICFSLRYV PTAGKLTVIV LEAKNLKKMD VGGLSDPYVK VHLLQGGKKV RKKKTTIKKN
     TLNPYYNEAF SFEVPCDQVQ KVQVELTVLD YDKLGKNEAI GRVAVGTAVG GAGLRHWADM
     LANPRRPIAQ WHSLRPPDRA RPIPAP
 
 
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