ID   SYTL3_HUMAN             Reviewed;         610 AA.
AC   Q4VX76; Q496J4; Q496J6; Q5U3B9;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 3.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Synaptotagmin-like protein 3;
DE   AltName: Full=Exophilin-6;
GN   Name=SYTL3; Synonyms=SLP3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLN-587.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP   GLN-587.
RC   TISSUE=Chondrosarcoma;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May act as Rab effector protein and play a role in vesicle
CC       trafficking. Binds phospholipids in the presence of calcium ions (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Binds NRXN1. Binds RAB27A that has been activated by
CC       GTP-binding via its N-terminus (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q4VX76; X5D778: ANKRD11; NbExp=3; IntAct=EBI-2840607, EBI-17183751;
CC       Q4VX76; O95190: OAZ2; NbExp=3; IntAct=EBI-2840607, EBI-1051861;
CC       Q4VX76; P51159: RAB27A; NbExp=3; IntAct=EBI-2840607, EBI-716881;
CC   -!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q4VX76-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q4VX76-2; Sequence=VSP_029403;
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DR   EMBL; AL589931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471051; EAW47653.1; -; Genomic_DNA.
DR   EMBL; BC085612; AAH85612.1; -; mRNA.
DR   EMBL; BC100830; AAI00831.1; -; mRNA.
DR   EMBL; BC100831; AAI00832.1; -; mRNA.
DR   CCDS; CCDS34563.1; -. [Q4VX76-2]
DR   CCDS; CCDS56458.1; -. [Q4VX76-1]
DR   RefSeq; NP_001009991.2; NM_001009991.3. [Q4VX76-2]
DR   RefSeq; NP_001229313.1; NM_001242384.1. [Q4VX76-1]
DR   RefSeq; NP_001229323.1; NM_001242394.1. [Q4VX76-1]
DR   RefSeq; NP_001305674.1; NM_001318745.1.
DR   RefSeq; XP_005267272.1; XM_005267215.4. [Q4VX76-1]
DR   RefSeq; XP_006715668.1; XM_006715605.3. [Q4VX76-1]
DR   RefSeq; XP_006715669.1; XM_006715606.3. [Q4VX76-1]
DR   RefSeq; XP_011534556.1; XM_011536254.2. [Q4VX76-1]
DR   AlphaFoldDB; Q4VX76; -.
DR   SMR; Q4VX76; -.
DR   BioGRID; 125119; 5.
DR   CORUM; Q4VX76; -.
DR   IntAct; Q4VX76; 6.
DR   MINT; Q4VX76; -.
DR   STRING; 9606.ENSP00000483936; -.
DR   iPTMnet; Q4VX76; -.
DR   PhosphoSitePlus; Q4VX76; -.
DR   BioMuta; SYTL3; -.
DR   DMDM; 259016380; -.
DR   EPD; Q4VX76; -.
DR   jPOST; Q4VX76; -.
DR   MassIVE; Q4VX76; -.
DR   PaxDb; Q4VX76; -.
DR   PeptideAtlas; Q4VX76; -.
DR   PRIDE; Q4VX76; -.
DR   ProteomicsDB; 62320; -. [Q4VX76-1]
DR   ProteomicsDB; 62321; -. [Q4VX76-2]
DR   Antibodypedia; 33442; 111 antibodies from 20 providers.
DR   DNASU; 94120; -.
DR   Ensembl; ENST00000360448.8; ENSP00000353631.4; ENSG00000164674.17. [Q4VX76-1]
DR   Ensembl; ENST00000367081.7; ENSP00000356048.4; ENSG00000164674.17. [Q4VX76-2]
DR   Ensembl; ENST00000611299.5; ENSP00000483936.1; ENSG00000164674.17. [Q4VX76-1]
DR   GeneID; 94120; -.
DR   KEGG; hsa:94120; -.
DR   MANE-Select; ENST00000611299.5; ENSP00000483936.1; NM_001242394.2; NP_001229323.1.
DR   UCSC; uc003qrp.3; human. [Q4VX76-1]
DR   CTD; 94120; -.
DR   DisGeNET; 94120; -.
DR   GeneCards; SYTL3; -.
DR   HGNC; HGNC:15587; SYTL3.
DR   HPA; ENSG00000164674; Low tissue specificity.
DR   neXtProt; NX_Q4VX76; -.
DR   OpenTargets; ENSG00000164674; -.
DR   PharmGKB; PA37986; -.
DR   VEuPathDB; HostDB:ENSG00000164674; -.
DR   eggNOG; KOG1028; Eukaryota.
DR   GeneTree; ENSGT00940000160610; -.
DR   HOGENOM; CLU_002711_0_0_1; -.
DR   InParanoid; Q4VX76; -.
DR   OMA; RKKKCNP; -.
DR   OrthoDB; 916843at2759; -.
DR   PhylomeDB; Q4VX76; -.
DR   TreeFam; TF341184; -.
DR   PathwayCommons; Q4VX76; -.
DR   SignaLink; Q4VX76; -.
DR   BioGRID-ORCS; 94120; 10 hits in 1073 CRISPR screens.
DR   ChiTaRS; SYTL3; human.
DR   GenomeRNAi; 94120; -.
DR   Pharos; Q4VX76; Tbio.
DR   PRO; PR:Q4VX76; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q4VX76; protein.
DR   Bgee; ENSG00000164674; Expressed in secondary oocyte and 135 other tissues.
DR   Genevisible; Q4VX76; HS.
DR   GO; GO:0070382; C:exocytic vesicle; IBA:GO_Central.
DR   GO; GO:0019897; C:extrinsic component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:Ensembl.
DR   GO; GO:0042043; F:neurexin family protein binding; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   CDD; cd04020; C2B_SLP_1-2-3-4; 1.
DR   Gene3D; 2.60.40.150; -; 2.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR041282; FYVE_2.
DR   InterPro; IPR010911; Rab_BD.
DR   InterPro; IPR043567; SYTL1-5_C2B.
DR   InterPro; IPR028704; SYTL3.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR45716:SF1; PTHR45716:SF1; 1.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF02318; FYVE_2; 1.
DR   SMART; SM00239; C2; 2.
DR   SUPFAM; SSF49562; SSF49562; 2.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS50916; RABBD; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Membrane; Reference proteome; Repeat.
FT   CHAIN           1..610
FT                   /note="Synaptotagmin-like protein 3"
FT                   /id="PRO_0000311116"
FT   DOMAIN          4..123
FT                   /note="RabBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00234"
FT   DOMAIN          306..428
FT                   /note="C2 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   DOMAIN          462..603
FT                   /note="C2 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   REGION          219..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..239
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         172..239
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_029403"
FT   VARIANT         414
FT                   /note="P -> S (in dbSNP:rs901363)"
FT                   /id="VAR_037137"
FT   VARIANT         540
FT                   /note="V -> I (in dbSNP:rs2291388)"
FT                   /id="VAR_037138"
FT   VARIANT         587
FT                   /note="L -> Q (in dbSNP:rs3123101)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT                   /id="VAR_037139"
SQ   SEQUENCE   610 AA;  68560 MW;  AFD69AFE759AC3C2 CRC64;
     MAQEIDLSAL KELEREAILQ VLYRDQAVQN TEEERTRKLK THLQHLRWKG AKNTDWEHKE
     KCCARCQQVL GFLLHRGAVC RGCSHRVCAQ CRVFLRGTHA WKCTVCFEDR NVKIKTGEWF
     YEERAKKFPT GGKHETVGGQ LLQSYQKLSK ISVVPPTPPP VSESQCSRSP GRLQEFGQFR
     GFNKSVENLF LSLATHVKKL SKSQNDMTSE KHLLATGPRQ CVGQTERRSQ SDTAVNVTTR
     KVSAPDILKP LNQEDPKCST NPILKQQNLP SSPAPSTIFS GGFRHGSLIS IDSTCTEMGN
     FDNANVTGEI EFAIHYCFKT HSLEICIKAC KNLAYGEEKK KKCNPYVKTY LLPDRSSQGK
     RKTGVQRNTV DPTFQETLKY QVAPAQLVTR QLQVSVWHLG TLARRVFLGE VIIPLATWDF
     EDSTTQSFRW HPLRAKAEKY EDSVPQSNGE LTVRAKLVLP SRPRKLQEAQ EGTDQPSLHG
     QLCLVVLGAK NLPVRPDGTL NSFVKGCLTL PDQQKLRLKS PVLRKQACPQ WKHSFVFSGV
     TPAQLRQSSL ELTVWDQALF GMNDRLLGGT RLGSKGDTAV GGDACSLSKL QWQKVLSSPN
     LWTDMTLVLH