SYTL5_HUMAN
ID SYTL5_HUMAN Reviewed; 730 AA.
AC Q8TDW5; A2RRF2;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Synaptotagmin-like protein 5;
GN Name=SYTL5; Synonyms=SLP5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH RAB27A, AND
RP INTERACTION WITH PHOSPHOLIPIDS.
RC TISSUE=Placenta;
RX PubMed=12051743; DOI=10.1016/s0006-291x(02)00320-0;
RA Kuroda T.S., Fukuda M., Ariga H., Mikoshiba K.;
RT "Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal
RT tandem C2 domains.";
RL Biochem. Biophys. Res. Commun. 293:899-906(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May act as Rab effector protein and play a role in vesicle
CC trafficking. Binds phospholipids.
CC -!- SUBUNIT: Binds RAB27A that has been activated by GTP-binding, and
CC possibly also RAB3A and RAB6A.
CC -!- INTERACTION:
CC Q8TDW5; Q8NHQ1: CEP70; NbExp=4; IntAct=EBI-2939487, EBI-739624;
CC Q8TDW5; O00194: RAB27B; NbExp=5; IntAct=EBI-2939487, EBI-10179046;
CC Q8TDW5; Q9BTA9: WAC; NbExp=3; IntAct=EBI-2939487, EBI-749118;
CC Q8TDW5; Q9ERI2: Rab27a; Xeno; NbExp=2; IntAct=EBI-2939487, EBI-398172;
CC Q8TDW5; P63011: Rab3a; Xeno; NbExp=2; IntAct=EBI-2939487, EBI-398393;
CC Q8TDW5; P35279: Rab6a; Xeno; NbExp=2; IntAct=EBI-2939487, EBI-444674;
CC Q8TDW5-2; P54252: ATXN3; NbExp=3; IntAct=EBI-12243980, EBI-946046;
CC Q8TDW5-2; Q96PX6: CCDC85A; NbExp=3; IntAct=EBI-12243980, EBI-7257229;
CC Q8TDW5-2; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-12243980, EBI-739624;
CC Q8TDW5-2; P51159: RAB27A; NbExp=3; IntAct=EBI-12243980, EBI-716881;
CC Q8TDW5-2; O00194: RAB27B; NbExp=3; IntAct=EBI-12243980, EBI-10179046;
CC Q8TDW5-2; O76024: WFS1; NbExp=3; IntAct=EBI-12243980, EBI-720609;
CC Q8TDW5-2; O95070: YIF1A; NbExp=3; IntAct=EBI-12243980, EBI-2799703;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8TDW5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TDW5-2; Sequence=VSP_042659;
CC -!- TISSUE SPECIFICITY: Highly expressed in placenta and liver.
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DR EMBL; AB080222; BAB88906.1; -; mRNA.
DR EMBL; AL121578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC131585; AAI31586.1; -; mRNA.
DR CCDS; CCDS14244.1; -. [Q8TDW5-1]
DR CCDS; CCDS55399.1; -. [Q8TDW5-2]
DR RefSeq; NP_001156806.1; NM_001163334.1. [Q8TDW5-2]
DR RefSeq; NP_001156807.1; NM_001163335.1. [Q8TDW5-1]
DR RefSeq; NP_620135.1; NM_138780.2. [Q8TDW5-1]
DR RefSeq; XP_011542303.1; XM_011544001.2. [Q8TDW5-2]
DR RefSeq; XP_011542304.1; XM_011544002.2. [Q8TDW5-2]
DR RefSeq; XP_016885461.1; XM_017029972.1. [Q8TDW5-2]
DR RefSeq; XP_016885462.1; XM_017029973.1. [Q8TDW5-2]
DR RefSeq; XP_016885463.1; XM_017029974.1. [Q8TDW5-2]
DR AlphaFoldDB; Q8TDW5; -.
DR SMR; Q8TDW5; -.
DR BioGRID; 125121; 16.
DR IntAct; Q8TDW5; 12.
DR STRING; 9606.ENSP00000395220; -.
DR iPTMnet; Q8TDW5; -.
DR PhosphoSitePlus; Q8TDW5; -.
DR BioMuta; SYTL5; -.
DR DMDM; 33301662; -.
DR EPD; Q8TDW5; -.
DR jPOST; Q8TDW5; -.
DR MassIVE; Q8TDW5; -.
DR MaxQB; Q8TDW5; -.
DR PaxDb; Q8TDW5; -.
DR PeptideAtlas; Q8TDW5; -.
DR PRIDE; Q8TDW5; -.
DR ProteomicsDB; 74354; -. [Q8TDW5-1]
DR ProteomicsDB; 74355; -. [Q8TDW5-2]
DR Antibodypedia; 10579; 98 antibodies from 23 providers.
DR DNASU; 94122; -.
DR Ensembl; ENST00000297875.7; ENSP00000297875.2; ENSG00000147041.12. [Q8TDW5-1]
DR Ensembl; ENST00000456733.2; ENSP00000395220.2; ENSG00000147041.12. [Q8TDW5-2]
DR GeneID; 94122; -.
DR KEGG; hsa:94122; -.
DR MANE-Select; ENST00000297875.7; ENSP00000297875.2; NM_138780.3; NP_620135.1.
DR UCSC; uc004ddv.4; human. [Q8TDW5-1]
DR CTD; 94122; -.
DR DisGeNET; 94122; -.
DR GeneCards; SYTL5; -.
DR HGNC; HGNC:15589; SYTL5.
DR HPA; ENSG00000147041; Tissue enhanced (brain, stomach).
DR neXtProt; NX_Q8TDW5; -.
DR OpenTargets; ENSG00000147041; -.
DR PharmGKB; PA37988; -.
DR VEuPathDB; HostDB:ENSG00000147041; -.
DR eggNOG; KOG1028; Eukaryota.
DR GeneTree; ENSGT00940000158618; -.
DR HOGENOM; CLU_002711_5_0_1; -.
DR InParanoid; Q8TDW5; -.
DR OMA; GHWKCSV; -.
DR OrthoDB; 916843at2759; -.
DR PhylomeDB; Q8TDW5; -.
DR TreeFam; TF341184; -.
DR PathwayCommons; Q8TDW5; -.
DR SignaLink; Q8TDW5; -.
DR BioGRID-ORCS; 94122; 8 hits in 694 CRISPR screens.
DR ChiTaRS; SYTL5; human.
DR GenomeRNAi; 94122; -.
DR Pharos; Q8TDW5; Tbio.
DR PRO; PR:Q8TDW5; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8TDW5; protein.
DR Bgee; ENSG00000147041; Expressed in pancreatic ductal cell and 127 other tissues.
DR Genevisible; Q8TDW5; HS.
DR GO; GO:0070382; C:exocytic vesicle; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042043; F:neurexin family protein binding; IBA:GO_Central.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd04029; C2A_SLP-4_5; 1.
DR CDD; cd04020; C2B_SLP_1-2-3-4; 1.
DR CDD; cd15766; FYVE_Slp5; 1.
DR Gene3D; 2.60.40.150; -; 2.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR037303; SLP-4/5_C2A.
DR InterPro; IPR028702; Slp5.
DR InterPro; IPR043567; SYTL1-5_C2B.
DR InterPro; IPR042783; SYTL5_FYVE.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45716:SF6; PTHR45716:SF6; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF02318; FYVE_2; 1.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; SSF49562; 2.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50916; RABBD; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Metal-binding; Phosphoprotein;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..730
FT /note="Synaptotagmin-like protein 5"
FT /id="PRO_0000190219"
FT DOMAIN 7..123
FT /note="RabBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00234"
FT DOMAIN 406..527
FT /note="C2 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 563..694
FT /note="C2 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT ZN_FING 64..106
FT /note="FYVE-type"
FT REGION 147..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 147
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80T23"
FT VAR_SEQ 384
FT /note="S -> STSSQAGSDRKWTYLNVPDADSD (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_042659"
FT VARIANT 275
FT /note="I -> V (in dbSNP:rs4827331)"
FT /id="VAR_024601"
FT VARIANT 302
FT /note="R -> C (in dbSNP:rs57226394)"
FT /id="VAR_061753"
SQ SEQUENCE 730 AA; 81523 MW; D9E0DA98880A95ED CRC64;
MSKNSEFINL SFLLDHEKEM ILGVLKRDEY LKKVEDKRIR KLKNELLEAK RRSGKTQQEA
SRVCVHCHRN LGLIFDRGDP CQACSLRVCR ECRVAGPNGS WKCTVCDKIA QLRIITGEWF
FEEKAKRFKQ VNVLGTDVVR QSILRRSPGA EEVQSQEQTR QDAEKSDTSP VAGKKASHDG
PKRKGFLLSK FRSATRGEII TPKTDTGRSY SLDLDGQHFR SLKSPPGSDR GSTGSSDLND
QEPGPRTPKS SRSNGVTPGT QSSPAPSTRT VTSVISREYG FENSMDLAAI EGTSQELTKS
HRRNTSGTPS IAVSGTSLSS DQSRSELDLS ESFTEDSEDT VSIRSKSVPG ALDKDSLEET
EESIDALVSS QLSTNTHRLA SGLSTTSLNS MMSVYSETGD YGNVKVSGEI LLHISYCYKT
GGLYIFVKNC RNLAIGDEKK QRTDAYVKSY LLPDKSRNNK RKTKIRTGTN PEFNETLKYT
ISHTQLETRT LQLSVWHYDR FGRNSFLGEV EIPFDSWNFE NPTDEWFVLQ PKVEFAPDIG
LQYKGELTVV LRYIPPEENL MLPPEQLQGN KTFKKGKKKE SPVISGGILE VFIKEAKNLT
AVKSGGTSDS FVKGYLLPDD SKATKHKTLV IKKSVNPQWN HTFMFSGIHP QDIKNVCLEL
TIWDKEAFSS NIFLGGVRLN SGSGVSHGKN VDWMDSQGEE QRLWQKMANN PGTPFEGVLM
LRSSMGKCRL
