SYTL5_RAT
ID SYTL5_RAT Reviewed; 753 AA.
AC Q812E4;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=Synaptotagmin-like protein 5;
GN Name=Sytl5; Synonyms=Slp5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Testis;
RX PubMed=12590134; DOI=10.1074/jbc.m213090200;
RA Fukuda M.;
RT "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through
RT interaction with the GDP-bound form of Rab27A in PC12 cells.";
RL J. Biol. Chem. 278:15390-15396(2003).
CC -!- FUNCTION: May act as Rab effector protein and play a role in vesicle
CC trafficking. Binds phospholipids (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds RAB27A that has been activated by GTP-binding.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}.
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DR EMBL; AB098162; BAC57423.1; -; mRNA.
DR RefSeq; NP_848016.1; NM_178333.1.
DR AlphaFoldDB; Q812E4; -.
DR SMR; Q812E4; -.
DR STRING; 10116.ENSRNOP00000004785; -.
DR iPTMnet; Q812E4; -.
DR PhosphoSitePlus; Q812E4; -.
DR PaxDb; Q812E4; -.
DR PRIDE; Q812E4; -.
DR GeneID; 302538; -.
DR KEGG; rno:302538; -.
DR UCSC; RGD:631342; rat.
DR CTD; 94122; -.
DR RGD; 631342; Sytl5.
DR eggNOG; KOG1028; Eukaryota.
DR InParanoid; Q812E4; -.
DR PhylomeDB; Q812E4; -.
DR PRO; PR:Q812E4; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0070382; C:exocytic vesicle; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042043; F:neurexin family protein binding; IBA:GO_Central.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; ISO:RGD.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd04029; C2A_SLP-4_5; 1.
DR CDD; cd04020; C2B_SLP_1-2-3-4; 1.
DR CDD; cd15766; FYVE_Slp5; 1.
DR Gene3D; 2.60.40.150; -; 2.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR037303; SLP-4/5_C2A.
DR InterPro; IPR028702; Slp5.
DR InterPro; IPR043567; SYTL1-5_C2B.
DR InterPro; IPR042783; SYTL5_FYVE.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45716:SF6; PTHR45716:SF6; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF02318; FYVE_2; 1.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; SSF49562; 2.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50916; RABBD; 1.
PE 2: Evidence at transcript level;
KW Membrane; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..753
FT /note="Synaptotagmin-like protein 5"
FT /id="PRO_0000190221"
FT DOMAIN 7..123
FT /note="RabBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00234"
FT DOMAIN 429..550
FT /note="C2 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 590..717
FT /note="C2 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT ZN_FING 64..106
FT /note="FYVE-type"
FT REGION 145..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..342
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 147
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80T23"
SQ SEQUENCE 753 AA; 83645 MW; 1D118D31B176A92D CRC64;
MSKNSEFINL SFLLDHEKEM ILGVLKRDEY LKKVEDKRIR KLKNELLEAK RRSGKTHQEA
NRVCVHCQKS LGLIFDRGAP CQACSLRVCS ECRVTGLDGS WKCTVCAKVA QLRIISGEWF
LEEKAKRFKQ VNVLGTDVVR QSILRRSPGS EEIQNQEQAH QGADKSDTLS SVRQKATHDG
PKRKGFLLSK FRSATRGEIK TPKAESGRSY SLDLDNQNLQ SFKSVSGSDR GSTTSSDLTD
QEAGRGAPKG SCSNGGIPVT QRSPAPSARS VTSISSREHG FENSMALATI ESISEELTKS
HRRNTSGTPS IAVSGTSLSS ERSRSELDLS ESFAEDLEDT SSIRSRSVPG ALDKDLNSLE
DTEDGVDLVS SRFSANTHSL ASGLSTSSQA GSDRKRSYLH VPDADSDTTS LNSMMSVYSE
TGDYGNVKVT GEILLHISYC YKTGGLYIFV KNCRNLAIGD EKKQRTDAYV KSYLLPDKTR
NNKRKTKIRT GTNPEFNETL KYTISHTQLE TRTLQLSVWH YDRFGRNSFL GEVEIAFDSW
NFENPCDEWF VLQPKVELAP DISLQYKGEL TIVLRYIPPE ENLIFPVEQP QGKKIFKKGK
KKESPAISGG ILEVFIKEAK NLTAVKAGGT SDSFVKGYLL PDDNKATKHK TAVVKKSVNP
QWNHVFIFSG LYPQDIQNAC LELTIWDKEA FSSNIFLGGV RLNSGSGISH GKAVDWMDSR
GEEQRLWQKM ADNPGTSVEG VLMLRSSMAK CRL
