ID   BOMB_BOMBO              Reviewed;          14 AA.
AC   P84214; P01296;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   09-NOV-2004, sequence version 1.
DT   11-DEC-2019, entry version 23.
DE   RecName: Full=Bombesin;
OS   Bombina bombina (Fire-bellied toad).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Bombinatoridae; Bombina.
OX   NCBI_TaxID=8345;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Skin secretion;
RX   PubMed=4537042; DOI=10.1016/0003-9861(72)90162-2;
RA   Anastasi A., Erspamer V., Bucci M.;
RT   "Isolation and amino acid sequences of alytesin and bombesin, two analogous
RT   active tetradecapeptides from the skin of European discoglossid frogs.";
RL   Arch. Biochem. Biophys. 148:443-446(1972).
CC   -!- FUNCTION: Stimulates smooth muscle contraction. Role in induction of
CC       hypothermia, stimulation of DNA replication and release of many
CC       gastrointestinal hormones (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:4537042}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:4537042}.
CC   -!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin family.
CC       {ECO:0000305}.
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DR   PIR; A01564; BSTD.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
DR   GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
DR   InterPro; IPR000874; Bombesin.
DR   Pfam; PF02044; Bombesin; 1.
DR   PROSITE; PS00257; BOMBESIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Direct protein sequencing;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..14
FT                   /note="Bombesin"
FT                   /id="PRO_0000043488"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         14
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   14 AA;  1638 MW;  CF36E4D3BCDC9666 CRC64;
     QQRLGNQWAV GHLM