ID   BOMB_BOMOR              Reviewed;         119 AA.
AC   P21591;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Bombesin;
DE   Flags: Precursor;
OS   Bombina orientalis (Oriental fire-bellied toad).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Bombinatoridae; Bombina.
OX   NCBI_TaxID=8346;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2263631; DOI=10.1073/pnas.87.24.9813;
RA   Spindel E.R., Gibson B.W., Reeve J.R. Jr., Kelly M.;
RT   "Cloning of cDNAs encoding amphibian bombesin: evidence for the
RT   relationship between bombesin and gastrin-releasing peptide.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:9813-9817(1990).
CC   -!- FUNCTION: Stimulates smooth muscle contraction. Role in induction of
CC       hypothermia, stimulation of DNA replication and release of many
CC       gastrointestinal hormones.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Localized to the cutaneous granular glands in the
CC       skin and the brain.
CC   -!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin family.
CC       {ECO:0000305}.
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DR   EMBL; M55255; AAA48551.1; -; mRNA.
DR   PIR; A39261; A39261.
DR   AlphaFoldDB; P21591; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
DR   InterPro; IPR000874; Bombesin.
DR   Pfam; PF02044; Bombesin; 1.
DR   PROSITE; PS00257; BOMBESIN; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Amphibian defense peptide; Cleavage on pair of basic residues;
KW   Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   PROPEP          30..44
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000003005"
FT   PEPTIDE         45..58
FT                   /note="Bombesin"
FT                   /id="PRO_0000003006"
FT   PROPEP          62..119
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000003007"
FT   MOD_RES         58
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   119 AA;  13863 MW;  3A3D84EA2445A44A CRC64;
     MSAIPLNRIL PLGFLFHLLI FSFISLSSCM EFVEDPNNQG RISLQQRLGN QWAVGHLMGK
     KSLQDTDFEE MESFAKRNVE NMRAALLQEQ NRAESERELR HAQLVVRNIL EQYLKNMQN