ID   BOMB_SANVA              Reviewed;          67 AA.
AC   P86483;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Bombesin {ECO:0000303|PubMed:19857598};
DE   Flags: Precursor;
OS   Sanguirana varians (Palawan frog) (Rana varians).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Sanguirana.
OX   NCBI_TaxID=367680;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 50-64, FUNCTION,
RP   SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PYROGLUTAMATE FORMATION AT
RP   GLN-50, AND AMIDATION AT MET-64.
RC   TISSUE=Skin {ECO:0000269|PubMed:19857598}, and
RC   Skin secretion {ECO:0000269|PubMed:19857598};
RX   PubMed=19857598; DOI=10.1016/j.cbpb.2009.10.007;
RA   Miao Y., Li W., Duan L., Xiao Y.;
RT   "A bombesin-like peptide from skin of Sanguirana varians.";
RL   Comp. Biochem. Physiol. 155:106-109(2010).
CC   -!- FUNCTION: Stimulates smooth muscle contraction in isolated rat stomach
CC       strip. {ECO:0000269|PubMed:19857598}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19857598}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin dorsal glands.
CC       {ECO:0000269|PubMed:19857598}.
CC   -!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin family.
CC       {ECO:0000255}.
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DR   AlphaFoldDB; P86483; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
DR   GO; GO:0045933; P:positive regulation of muscle contraction; IDA:UniProtKB.
DR   InterPro; IPR000874; Bombesin.
DR   Pfam; PF02044; Bombesin; 1.
DR   PROSITE; PS00257; BOMBESIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   PROPEP          31..49
FT                   /evidence="ECO:0000255, ECO:0000269|PubMed:19857598"
FT                   /id="PRO_0000394189"
FT   PEPTIDE         50..64
FT                   /note="Bombesin"
FT                   /evidence="ECO:0000269|PubMed:19857598"
FT                   /id="PRO_0000394190"
FT   MOD_RES         50
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:19857598"
FT   MOD_RES         64
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:19857598"
SQ   SEQUENCE   67 AA;  7491 MW;  850EAC2A8EF1CB4F CRC64;
     MSLLPAVKVL PLGYLGIVLV FSLILRSAMV DFIQDAGKLE RIDTYKREAQ MIFGAPMWAL
     GHLMGRK