ID   BOML2_BOMVA             Reviewed;          13 AA.
AC   P84211;
DT   09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   09-NOV-2004, sequence version 1.
DT   11-DEC-2019, entry version 26.
DE   RecName: Full=Bombesin-like peptide 2;
OS   Bombina variegata (Yellow-bellied toad).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Bombinatoridae; Bombina.
OX   NCBI_TaxID=8348;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:15134346};
RX   PubMed=15134346; DOI=10.1515/bc.2004.027;
RA   Marenah L., Flatt P.R., Orr D.F., McClean S., Shaw C., Abdel-Wahab Y.H.;
RT   "Skin secretion of the toad Bombina variegata contains multiple insulin-
RT   releasing peptides including bombesin and entirely novel insulinotropic
RT   structures.";
RL   Biol. Chem. 385:315-321(2004).
CC   -!- FUNCTION: Possesses insulin-releasing activity.
CC       {ECO:0000269|PubMed:15134346}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15134346}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:15134346}.
CC   -!- MASS SPECTROMETRY: Mass=1662.6; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:15134346};
CC   -!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0005179; F:hormone activity; TAS:UniProtKB.
DR   GO; GO:0006952; P:defense response; TAS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
DR   GO; GO:0050796; P:regulation of insulin secretion; IDA:UniProtKB.
DR   InterPro; IPR000874; Bombesin.
DR   Pfam; PF02044; Bombesin; 1.
DR   PROSITE; PS00257; BOMBESIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Direct protein sequencing;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..13
FT                   /note="Bombesin-like peptide 2"
FT                   /id="PRO_0000043490"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P84213"
FT   MOD_RES         13
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P84213"
SQ   SEQUENCE   13 AA;  1566 MW;  CF380C70FF58C366 CRC64;
     QSFGNQWARG HFM