ID   BOP1B_XENLA             Reviewed;         728 AA.
AC   Q7ZXX9;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Ribosome biogenesis protein bop1-B {ECO:0000255|HAMAP-Rule:MF_03027};
DE   AltName: Full=Block of proliferation 1 protein B {ECO:0000255|HAMAP-Rule:MF_03027};
GN   Name=bop1-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the PeBoW complex, which is required for
CC       maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBUNIT: Component of the PeBoW complex, composed of bop1, pes1 and
CC       wdr12. The complex is held together by bop1, which interacts with pes1
CC       via its N-terminal domain and with wdr12 via a high-affinity
CC       interaction between the seven-bladed beta-propeller domains of the 2
CC       proteins. The PeBoW complex associates with the 66S pre-ribosome.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; BC044074; AAH44074.1; -; mRNA.
DR   RefSeq; NP_001080358.1; NM_001086889.1.
DR   AlphaFoldDB; Q7ZXX9; -.
DR   SMR; Q7ZXX9; -.
DR   DNASU; 380050; -.
DR   GeneID; 380050; -.
DR   KEGG; xla:380050; -.
DR   CTD; 380050; -.
DR   Xenbase; XB-GENE-6254226; bop1.L.
DR   OrthoDB; 759498at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 380050; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..728
FT                   /note="Ribosome biogenesis protein bop1-B"
FT                   /id="PRO_0000370389"
FT   REPEAT          393..432
FT                   /note="WD 1"
FT   REPEAT          434..474
FT                   /note="WD 2"
FT   REPEAT          514..556
FT                   /note="WD 3"
FT   REPEAT          559..597
FT                   /note="WD 4"
FT   REPEAT          600..639
FT                   /note="WD 5"
FT   REPEAT          643..682
FT                   /note="WD 6"
FT   REPEAT          698..728
FT                   /note="WD 7"
FT   REGION          1..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..114
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   728 AA;  83465 MW;  C51F4712E4B3531B CRC64;
     MKRGSKRESG GPLTEEPEPL FSEENRSLQD GNPLDESDSE ESQYSGLEDS GTDSSDDEED
     HSSEEVQDPG KSPKEIIKVP HRTSKSQADS PADEEDQPNE IKEYENDSSD EEDIRNTVGN
     IPMEWYKDLP HIGYDLDGRK IFKPLRSKDQ LEEFLDKMEN PDYWRTVHDK KTGQDIKLTD
     EQVDLVERLQ KGQFGDLNYD PYQPAIDFFT HETMIHPVTN RPADKRSFIP SLIEKEKVSK
     LVHAIKMGWI QPRKPRDDAP TYYDLWAKED PNAILGRHKM HVPAPKLPLP GHEQSYNPPP
     EYLMSEEERL AWEQQDPEDR KLPFLPQRFN CLRAVPGYAR FIHERFERCL DLYLCPRQRK
     MRVNVDPEDL IPKLPKPRDL QPFPTIQSMI YKGHKDLVRC ISVSPSGQWL VSGSDDCSVR
     FWEVSTGRCM KSVVLEGAVK SISWNPNPVL VLVAACVDRS VVLINPGLGD RLLCSATDQH
     ISGYQPPEEE VQQPVTWEEA EGSEYSSGLR LWIKHQKEVK QVTFHARGDY FAVVLPDNGN
     SQVLIHQLSR RRSQNPFRKN KGQVQKVLFH PTRPFFFVAT QRYVRVYNLL KQELTKKLLT
     NCKWVSSIAV HPAGDNLICG SYDSKLAWFD MDLSTKPYKV LRHHKKALRA VSFHKSYPLF
     ASGSDDASVI VCHGMVYNDL LQNPLIVPVK VLRGHAIHRD LGVLDVMFHP TQPWVFSSGA
     DGTIRLFT