BOP1_AEDAE
ID BOP1_AEDAE Reviewed; 866 AA.
AC Q17LZ2;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN ORFNames=AAEL001169;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; CH477209; EAT47752.1; -; Genomic_DNA.
DR RefSeq; XP_001658204.1; XM_001658154.1.
DR AlphaFoldDB; Q17LZ2; -.
DR SMR; Q17LZ2; -.
DR STRING; 7159.AAEL001169-PA; -.
DR GeneID; 5568838; -.
DR KEGG; aag:5568838; -.
DR VEuPathDB; VectorBase:AAEL001169; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_1_0_1; -.
DR InParanoid; Q17LZ2; -.
DR OMA; MRPAKGE; -.
DR OrthoDB; 759498at2759; -.
DR PhylomeDB; Q17LZ2; -.
DR Proteomes; UP000008820; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..866
FT /note="Ribosome biogenesis protein BOP1 homolog"
FT /id="PRO_0000370391"
FT REPEAT 527..566
FT /note="WD 1"
FT REPEAT 568..608
FT /note="WD 2"
FT REPEAT 697..735
FT /note="WD 3"
FT REPEAT 738..777
FT /note="WD 4"
FT REPEAT 781..820
FT /note="WD 5"
FT REPEAT 836..866
FT /note="WD 6"
FT REGION 1..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..145
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 866 AA; 99305 MW; 8F7B3CEBF0D56182 CRC64;
MVANKDKATK RKIPAVDDAV KVSTANGKQQ TKLKEPVDDE SASDYYESDE ENLFASIDNG
NDEDSTDSEG EGEESDDEEV QEFESADSDF EDESGKDDEE EAEDEEDDAD EEDADSADDV
NSDSSPEPEE EESDDELEFE EDLEEPEQPK AIQKVIVGRQ KKSVEATAED EDEEDDEETR
DLLEAAQKED EKLGEIDAAL GIAPAKTRGV GIFPPEAKSR FKGGKNQDEY AAGDTSDEED
IRNTVGNIPM HWYDEYKHIG YDWEGNRLIK PAKTDAIDDF LKKMEDPNFW RTVKDPQTGQ
NVVLTDEDIG LIKRIMAGKN PDEQYSDYEP WIEWFTSEVE KMPIRNIPDH KRSFLPSKSE
KQKVGRLVHA LKMGWIKTRA ETERLAALSK GPKFYMIWES DHGKEEMRRI HDHVVAPKRP
LPGHAESYNP PPEYLFNEQE LAEWNSHEEE PWKRKLHYVP QKFNSLREVP YYDKYIRERF
LRCLDLYLCP RGKRTRVTVG PEYLIPKLPS PKDLQPFPTL QNLIYKGHTD MIRSVSIEPK
GEYLVTGSDD QTVKIWEVST ARCIRTIPTG DVVRSVAWCP NSKISLIAVA SGKRVLLINP
QVGDSLLVKK TDDLLAEAPK SETVDNERIT TAVQWVDFTE EERKSGVRIV INHFKEIKQV
TWHGRGDYFA TVMPEAANRS VLIHQLSKRR SQFPFSKSKG LIQCVLFHPV KPCLFVATQR
HVRVYDLVKQ ELLKKLFPSC KWISSMAIHP KGDNLLVATY EKKMMWFDLD LSTRPYQQLK
LHHSAIRNVA FHLRYPLFAS ASDDRSVIVS HGMVYNDLLQ NPLIVPLRRL EHHERVNDFG
AFDVVFHPTQ PWLFSSGADN TVRLYT
