ID   BOP1_ANOGA              Reviewed;         865 AA.
AC   Q7PTC5;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 4.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN   ORFNames=AGAP007128;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; AAAB01008807; EAA04116.5; -; Genomic_DNA.
DR   RefSeq; XP_308633.4; XM_308633.4.
DR   AlphaFoldDB; Q7PTC5; -.
DR   SMR; Q7PTC5; -.
DR   STRING; 7165.AGAP007128-PA; -.
DR   PaxDb; Q7PTC5; -.
DR   GeneID; 1269978; -.
DR   KEGG; aga:AgaP_AGAP007128; -.
DR   CTD; 1269978; -.
DR   VEuPathDB; VectorBase:AGAP007128; -.
DR   eggNOG; KOG0650; Eukaryota.
DR   HOGENOM; CLU_011390_1_0_1; -.
DR   InParanoid; Q7PTC5; -.
DR   OMA; MRPAKGE; -.
DR   OrthoDB; 759498at2759; -.
DR   PhylomeDB; Q7PTC5; -.
DR   Proteomes; UP000007062; Chromosome 2L.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IBA:GO_Central.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..865
FT                   /note="Ribosome biogenesis protein BOP1 homolog"
FT                   /id="PRO_0000370392"
FT   REPEAT          526..565
FT                   /note="WD 1"
FT   REPEAT          567..607
FT                   /note="WD 2"
FT   REPEAT          651..693
FT                   /note="WD 3"
FT   REPEAT          696..734
FT                   /note="WD 4"
FT   REPEAT          737..776
FT                   /note="WD 5"
FT   REPEAT          780..819
FT                   /note="WD 6"
FT   REPEAT          835..865
FT                   /note="WD 7"
FT   REGION          1..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          207..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..159
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..195
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   865 AA;  99298 MW;  51C57E1F714E5B72 CRC64;
     MVANKERAIK RKASEGGAKP EPITSKQEPL DESNDEDNSN ESDYESDKEN LLGSIENEGE
     DSSDSDGEYA TDDDEDDVLS FESLNSDGEE EDEEEDAGTT LEEVEREAEE DDDEEDGEDD
     EEADSADDVN SDSSPEEDEG DLEDSSDEEL EEEEEEEEAK ENGKEKPAKA KAERKQREEQ
     FESDDEPLPD DLKLGRIEDV LGTGEKKTRG LGVFPPVPKR KGKAAQDEYA AGDTSDEEDI
     RNTVGNIPMH WYDEYKHVGY DWDAKKIIKA KKGDAIDDFL QRMEDPNFWR TVTDPQTGQK
     VVLSDEDIGL IKRIMSGRNP DAEYDDYEPF IEWFTSEVEK MPIRNIPESK RSFLPSKAEK
     HKIGRYVHAL KMGWMKTMAE KRRLEAIRRQ PKFYMLWTTD HGKEEMRRIH DHVAAPKRML
     PGHAESYNPP PEYLFDEKEL EEWNKLANQP WKRKRAYVPQ KYNSLREVPG YTRYVKERFL
     RCLDLYLAPR MRRSRVAVGA EYLIPKLPSP RDLQPFPTLQ NLIYTGHTSL IRCISVEPKG
     EYIVTGSDDM TVKIWEISTA RCIRTIPTGD IVRSVAWCPN SKISLVAAAS GKRVLLINPK
     VGDYMLVKKT DDLLTEAPRS DTVDSERIRS AVQWGEVTEE EKKLGVRIVI THFREVRQVT
     WHGRGDYFAT VMPDGAYRSV MIHQLSKRRS QVPFSKSKGL IQCVLFHPIK PCLFVATQRH
     IRVYDLVKQL MMKKLYPGCK WISSMAIHPK GDNLLIGTYE KRLMWFDLDL STKPYQQLRI
     HNAAIRSVAF HPRYPLFASA GDDRSVIVSH GMVYNDLLQN PLIVPLRRLK NHAVVNDFSV
     FDVVFHPTQP WVFSSGADNT VRLYT