ID   BOP1_BRUMA              Reviewed;         642 AA.
AC   A8PWB6;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN   ORFNames=Bm1_36175;
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17885136; DOI=10.1126/science.1145406;
RA   Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA   Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA   Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA   Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA   Pop M., White O., Barton G.J., Carlow C.K.S., Crawford M.J., Daub J.,
RA   Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA   Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.-W.,
RA   Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA   McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA   Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA   Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA   Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA   Blaxter M.L., Scott A.L.;
RT   "Draft genome of the filarial nematode parasite Brugia malayi.";
RL   Science 317:1756-1760(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; DS239410; EDP32545.1; -; Genomic_DNA.
DR   RefSeq; XP_001898681.1; XM_001898646.1.
DR   AlphaFoldDB; A8PWB6; -.
DR   SMR; A8PWB6; -.
DR   STRING; 6279.A8PWB6; -.
DR   EnsemblMetazoa; Bm13748.1; Bm13748.1; WBGene00234009.
DR   GeneID; 6102121; -.
DR   KEGG; bmy:BM_BM13748; -.
DR   WBParaSite; Bm13748.1; Bm13748.1; WBGene00234009.
DR   CTD; 6102121; -.
DR   WormBase; Bm13748; BM03556; WBGene00234009; -.
DR   HOGENOM; CLU_011390_2_0_1; -.
DR   InParanoid; A8PWB6; -.
DR   OrthoDB; 759498at2759; -.
DR   Proteomes; UP000006672; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..642
FT                   /note="Ribosome biogenesis protein BOP1 homolog"
FT                   /id="PRO_0000370405"
FT   REPEAT          311..351
FT                   /note="WD 1"
FT   REPEAT          353..393
FT                   /note="WD 2"
FT   REPEAT          472..510
FT                   /note="WD 3"
FT   REPEAT          513..552
FT                   /note="WD 4"
FT   REPEAT          556..595
FT                   /note="WD 5"
FT   REPEAT          612..642
FT                   /note="WD 6"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   642 AA;  74104 MW;  3FE010AF670AD7A1 CRC64;
     MIHKRMNSTE LERTSKKIDD YDSSDEEDLR NTIGNIPISW YDDFSHVGYD KDGNQIESAK
     KNDDMEEFLD RMDDSNYWRR VYDRQSGGFV TLNDEEVKKL NALDASKYPL VGYNPYQPFL
     DIFSSQTEIH PISNRPDSKR SFIPSLDEKR LVGKMVHAIK MGWVRPSRPK QIEKRVYDLW
     ADNPCSEKTK TELARIRMHF PAPKVPLPGH AESYNPPAEY LCDEEELKKW EETDPEDRRL
     DFIPKKYDCL RKVPAYDRFY NDRYQRCLDL YLAPRQRKMK LNIDHTELLP ELPNLTDMRP
     FPTTQSFLML GHSGQVRSLS FEPESTEIFA SGGEDGTLRL WSICDGRCLK TTSLDGSITS
     VAYCPLAKWT LLAVTMESNK MILTNSYCGD RHRITTTTEY LSKLRCESSE SDVLKWKYEG
     KGTLSVDLGY IARQVVWHHK GDYFATFANS KSPKLIYIHQ LSKCKSQRPF SRLKGLMTVL
     SFHPSEPFLF VGTQRYIRIY DLAKCQLKKK IITGSQWMSC MHVDFRGDNV FVGGHDRVFS
     WIDLQLSSKP WKSVKHHTAA IRGVTQHARC PLIATVSDDS TAIVYYARIS SDSLKENEFV
     PVRRLRTQTA QKNGLSILAA IFHPSQPWLI TAHVDGSIAL FT