ID   BOP1_CAEEL              Reviewed;         674 AA.
AC   Q9U2A9;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN   ORFNames=Y48B6A.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; AL110490; CAB54439.1; -; Genomic_DNA.
DR   PIR; T26995; T26995.
DR   RefSeq; NP_496956.1; NM_064555.4.
DR   AlphaFoldDB; Q9U2A9; -.
DR   SMR; Q9U2A9; -.
DR   BioGRID; 40351; 24.
DR   STRING; 6239.Y48B6A.1; -.
DR   EPD; Q9U2A9; -.
DR   PaxDb; Q9U2A9; -.
DR   PeptideAtlas; Q9U2A9; -.
DR   PRIDE; Q9U2A9; -.
DR   EnsemblMetazoa; Y48B6A.1.1; Y48B6A.1.1; WBGene00012978.
DR   GeneID; 175069; -.
DR   KEGG; cel:CELE_Y48B6A.1; -.
DR   UCSC; Y48B6A.1; c. elegans.
DR   CTD; 175069; -.
DR   WormBase; Y48B6A.1; CE22116; WBGene00012978; -.
DR   eggNOG; KOG0650; Eukaryota.
DR   GeneTree; ENSGT00390000018422; -.
DR   HOGENOM; CLU_011390_2_0_1; -.
DR   InParanoid; Q9U2A9; -.
DR   OMA; MRPAKGE; -.
DR   OrthoDB; 759498at2759; -.
DR   PhylomeDB; Q9U2A9; -.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q9U2A9; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00012978; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IBA:GO_Central.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..674
FT                   /note="Ribosome biogenesis protein BOP1 homolog"
FT                   /id="PRO_0000370407"
FT   REPEAT          342..384
FT                   /note="WD 1"
FT   REPEAT          386..425
FT                   /note="WD 2"
FT   REPEAT          427..458
FT                   /note="WD 3"
FT   REPEAT          459..500
FT                   /note="WD 4"
FT   REPEAT          503..541
FT                   /note="WD 5"
FT   REPEAT          587..626
FT                   /note="WD 6"
FT   REPEAT          643..674
FT                   /note="WD 7"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   674 AA;  77381 MW;  FBF719D30EECFA85 CRC64;
     MASTSAATPL KNKRKFENGK KKPKTLKDEF GEKLDIKPVI VPPKPADEYD YDSSDEEDLR
     NTIGNIPIKW YDDEDHIGYD KFGEKIAKPA KKGEIETFLE KMEDPDYWRK VFDKQTGTDV
     KLTDEQIEKI HNIATGKYPT IGYNPYEPFL DIFSSQKEIH PIDNRPEPKS RFIPSKDEMR
     MVSRMVHAIK MGWAKGPRAK KEEHKSYDLW ASEDALDNVT KSQLSRMRVH MPAPKVALPT
     HAESYNPPEE YIFDDEERKK WEEAEKEDRV LNFMPSKYDA LRKVPQYDKF ITERFERCLD
     LYLAPRQRKM RIHADPTDLL PDLPNPNDLR PFPTTLAFYM RGHTGQVRAI TVEPERGELL
     ASGGEDGTVR IWMIATGRCI KTFQMDGEVT SVSFSPVADR TLLAVAYEGK YVAILNTGCG
     DRLHVQQTEA LLAETPTDAQ EDGAVVTWRK SKEKLMLKMP NEVRQVTWHS KGDYFASVAI
     DDIAKSVYVH QLSKAKSQCP FQKRKGHVQA VTFHPTQARL FVATKIHVRE YDLARCVLVK
     KLITGCKHIS TMATDANGEN LFLGGLDRRF CWMDLQMGNK PWKKLKHHTA AVRSVAYHKK
     YPLLATVSDD GTAMVYYARI YTDFVKDNEL YPVKRLRAHE KTPNDLCMLH TTWHPTQPWL
     ITAGADGTIA LFTY