BOP1_CULQU
ID BOP1_CULQU Reviewed; 861 AA.
AC B0WC36;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN ORFNames=CPIJ004506;
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB;
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; DS231885; EDS43188.1; -; Genomic_DNA.
DR RefSeq; XP_001846270.1; XM_001846218.1.
DR AlphaFoldDB; B0WC36; -.
DR SMR; B0WC36; -.
DR STRING; 7176.CPIJ004506-PA; -.
DR GeneID; 6036185; -.
DR KEGG; cqu:CpipJ_CPIJ004506; -.
DR VEuPathDB; VectorBase:CPIJ004506; -.
DR VEuPathDB; VectorBase:CQUJHB008707; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_1_0_1; -.
DR InParanoid; B0WC36; -.
DR OMA; MRPAKGE; -.
DR OrthoDB; 759498at2759; -.
DR PhylomeDB; B0WC36; -.
DR Proteomes; UP000002320; Partially assembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..861
FT /note="Ribosome biogenesis protein BOP1 homolog"
FT /id="PRO_0000370393"
FT REPEAT 522..561
FT /note="WD 1"
FT REPEAT 563..603
FT /note="WD 2"
FT REPEAT 692..730
FT /note="WD 3"
FT REPEAT 733..772
FT /note="WD 4"
FT REPEAT 776..815
FT /note="WD 5"
FT REPEAT 831..861
FT /note="WD 6"
FT REGION 1..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..141
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 861 AA; 98335 MW; 99A6B3FB84ADE57E CRC64;
MVANKSKATK RKVAAAPQPP TAQDKPATNG RSTKQPEADS DQSASDYYES DEENLLANIN
NDDGDSSDSE GEGDASDGEV QGLNIESDSD FEEDDQEADG EEEEEDSADD VNSDSSPEED
EGESEEEEED DDEGDLEFEE DLAEPEKPRA IKEGSKAGKK QAPEVESEEE DDLETKKLLE
AAAKEDEKLA ALDSVLGPDG EKKTRGVGSF PPERKTGRLK NSDEYAGGDT SDEEDIRNTV
GNIPMHWYDE YKHIGYDWDG NRLIKPPKMD TIDEFLKRME DPNFWRTVKD PQTGQNVVLS
DEDVGLIKRI MAGRNPDQQY NDYEPWIEWF TSEVEKMPIR NIPDHKRSFL PSKSEKQKIG
RLVHALKMGW VKTRAETERL AAAAKGPKFY MVWDSDHGKE DIRRIHDHVV APKRPLPGHA
ESYNPPPEYL FNERELAEWN SHEEEPWRRK LHYIPQKFNS LREVPYYAQY VRERFLRCLD
LYLCPRGKRT RVTVGPEYLI PKLPSPKDLQ PFPTLQNLVY RGHTDMIRTI SIEPKGEYLV
TGSDDKTIKI WEVSTARCIK TIPTGDVVRS VAWCPNVKIS LIAVASGKRT LLINPHVGDC
LLSKKTDDLL AEAPKHEVVD NERISTAVQW VDVAEEEQKA GVRIVINHFR EIKQVTWHGR
GDYFATVMPE AQNRSVLIHQ LSKRRSQFPF SKSKGLIQCV LFHPVKPCLF VATQRHIRVY
DLVKQELLKK LFPSCKWISS MAIHPKGDNL LVATYEKKMM WFDLDLSTRP YQQLKLHFSA
IRNVAFHQRY PLFASASDDR SVIVSHGMVY NDLMQNALIV PLRRLENHER VNDFGAFDVV
FHPTQPWLFS SGADNTVRLY T
