BOP1_DICDI
ID BOP1_DICDI Reviewed; 833 AA.
AC Q54TD8;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN ORFNames=DDB_G0281839;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; AAFI02000043; EAL66479.1; -; Genomic_DNA.
DR RefSeq; XP_640451.1; XM_635359.1.
DR AlphaFoldDB; Q54TD8; -.
DR SMR; Q54TD8; -.
DR STRING; 44689.DDB0237686; -.
DR PaxDb; Q54TD8; -.
DR EnsemblProtists; EAL66479; EAL66479; DDB_G0281839.
DR GeneID; 8623264; -.
DR KEGG; ddi:DDB_G0281839; -.
DR dictyBase; DDB_G0281839; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_1_0_1; -.
DR InParanoid; Q54TD8; -.
DR OMA; MRPAKGE; -.
DR PhylomeDB; Q54TD8; -.
DR Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q54TD8; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005730; C:nucleolus; ISS:dictyBase.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; ISS:dictyBase.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:dictyBase.
DR GO; GO:0006364; P:rRNA processing; ISS:dictyBase.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..833
FT /note="Ribosome biogenesis protein BOP1 homolog"
FT /id="PRO_0000370408"
FT REPEAT 331..370
FT /note="WD 1"
FT REPEAT 488..527
FT /note="WD 2"
FT REPEAT 529..569
FT /note="WD 3"
FT REPEAT 618..660
FT /note="WD 4"
FT REPEAT 663..701
FT /note="WD 5"
FT REPEAT 704..743
FT /note="WD 6"
FT REPEAT 747..786
FT /note="WD 7"
FT REPEAT 802..833
FT /note="WD 8"
FT REGION 20..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..112
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 95504 MW; E8C5D962D76CF054 CRC64;
MNKSKVTSKK VVAETKVVNN KKSEPIAVSE PKKSVSKPTT TATTTVSKSP VSTITTQILG
KRTKTPVVRD EENEDEKLDF GNIDLNNYNS EDDEDYESEE DDEGDDEEDV ESQNGSIVYS
ESEEEEEGGI NKALLEAEES LVEYQSEDDS GSISSKSSSS TTTTTTTTKK TNNDEEEVAP
NKQWTNDPNQ FYDSDDSSED ESLVNRIGNI PLEWYDDYDH IGYDVDGNKI MKTESMKDSI
DKYLDQQDPN FWRTVYDKVN DKKVVLSDDD MALLKSIQNK HFIPGYDPYA DWYDSGNNHP
DSIHPMHNAP VPKRSFFPNG TDEEREIRRL TKAIRMGWIK LNKKGKKGEK DKKDGNFDLW
ADEGEEKEKT KGIRRIAAPK QKLPGNVESF NPPEEYLLNE NELKAWHLMD PRERPHNFIP
QKYQSLRQLP IYNKLIKERF ERCLDLYLCP RTTRVKQFTK DPTKFLPTLP KPQDLRPFPS
HEEIQFLGHK ARVRSISISP NGQWLASGSD DCTIKIWEVS STRCLYSLEV ESEVQTVAWN
PNPIYNILAV GYSNKIIIIT PPLFGTQTEH SPETEKILTK PPTDSSTEQQ QNKSVNWYQV
TGADKAKLLE KGVRIEIHHP FTVKNLTWHY KGDYFSTTSP EEGTRSVKIH HLSKRATQSP
FRKSKTPNQV TRFHPNKPIF FVADQNIIRV YDLMKQELIK KLITGCRYIS SIDIHPQGDN
VIMGGYDKKV CWFDLDLSVR PYKVLNYHKM AVRKVIYHPT LPLFASCSDD LSIHVFHGMV
YDDLLQNALI VPLKILKTHE SINDLGVLDI VFHPKQPWIF SSGADSTIRL YTN
