ID   BOP1_DROAN              Reviewed;         793 AA.
AC   B3MHX6;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN   ORFNames=GF11675;
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; CH902619; EDV36963.1; -; Genomic_DNA.
DR   RefSeq; XP_001960141.1; XM_001960105.2.
DR   AlphaFoldDB; B3MHX6; -.
DR   SMR; B3MHX6; -.
DR   STRING; 7217.FBpp0114867; -.
DR   EnsemblMetazoa; FBtr0116375; FBpp0114867; FBgn0088715.
DR   GeneID; 6494539; -.
DR   KEGG; dan:6494539; -.
DR   eggNOG; KOG0650; Eukaryota.
DR   HOGENOM; CLU_011390_2_0_1; -.
DR   InParanoid; B3MHX6; -.
DR   OMA; MRPAKGE; -.
DR   OrthoDB; 759498at2759; -.
DR   PhylomeDB; B3MHX6; -.
DR   Proteomes; UP000007801; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0035206; P:regulation of hemocyte proliferation; IEA:EnsemblMetazoa.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..793
FT                   /note="Ribosome biogenesis protein BOP1 homolog"
FT                   /id="PRO_0000370394"
FT   REPEAT          454..495
FT                   /note="WD 1"
FT   REPEAT          497..535
FT                   /note="WD 2"
FT   REPEAT          579..621
FT                   /note="WD 3"
FT   REPEAT          624..662
FT                   /note="WD 4"
FT   REPEAT          665..704
FT                   /note="WD 5"
FT   REPEAT          708..747
FT                   /note="WD 6"
FT   REPEAT          763..793
FT                   /note="WD 7"
FT   REGION          1..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..69
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..114
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..135
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..168
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   793 AA;  91340 MW;  B6DF03CC44546E6A CRC64;
     MTKKLTLKRK GKEPEPTNEV AASSEASDNE EEEDLLQAVK DPGEDTTDDE GIDQEYQSDS
     SEDLEFESDE EGNYLGRKKG DGSSEEEDDD GDEEGEEEDE EEDDSEDGES ADDGDEEKPT
     TSKQNKSEDE PSSSKVSKKT QPPTKDLVKR DPSHPEYHDS DTSDEEDIRN TVGNIPMHWY
     DEYKHIGYDW DAKKIVKPPQ GDQIDEFLRK IEDPNFWRTV KDPQTGQEVL ITDEDIALIK
     RIISGRIPNK DHNEYEPWVE WFTSEVEKMP IKNVPDHKRS FLPSVSEKKR VGRMVHALKM
     GWMKTTEEVE REKQAKRGPK FYMLWETDTS REHMRRIHDP VSAPKRDLPG HAESYNPPPE
     YLFDERETKE WLKLKDEPHK RKLHFMPQKF TSLRAVPAYS RYLRERFLRC LDLYLCPRAK
     RVKLNIDAEY LIPKLPSPRD LQPFPTIESL VYRGHTDLVR SVSVEPKGEY IVSGSDDKTV
     KIWEIATGRC IRTIETEDVV RCVAWCPNAK LSIIAVATGN RLLLINPKVG DKVLVKKTDD
     LLAEEPSSDV IESERIKAAV QWATAEPAEQ EKGVRVVINH FKPIRQVTWH GRGDYLATVM
     PEGANRSALI HQLSKRRSQI PFSKSKGLIQ CVLFHPVKPC FFVATQHNIR IYDLVKQELV
     KKLLTNSKWI SGMSIHPKGD NLLVSTYDKK MLWFDLDLST KPYQTMRLHR NAVRSVAFHL
     RYPLFASGSD DQAVIVSHGM VYNDLLQNPL IVPLKKLQTH EKREDFGVLD VNWHPIQPWI
     FSTGADCTIR LYT