ID   BOP1_DROGR              Reviewed;         786 AA.
AC   B4J9K1;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN   ORFNames=GH22027;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; CH916367; EDW02508.1; -; Genomic_DNA.
DR   RefSeq; XP_001987641.1; XM_001987605.1.
DR   AlphaFoldDB; B4J9K1; -.
DR   SMR; B4J9K1; -.
DR   STRING; 7222.FBpp0155933; -.
DR   EnsemblMetazoa; FBtr0157441; FBpp0155933; FBgn0129488.
DR   GeneID; 6559538; -.
DR   KEGG; dgr:6559538; -.
DR   eggNOG; KOG0650; Eukaryota.
DR   HOGENOM; CLU_011390_0_1_1; -.
DR   InParanoid; B4J9K1; -.
DR   OMA; MRPAKGE; -.
DR   OrthoDB; 759498at2759; -.
DR   PhylomeDB; B4J9K1; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0035206; P:regulation of hemocyte proliferation; IEA:EnsemblMetazoa.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..786
FT                   /note="Ribosome biogenesis protein BOP1 homolog"
FT                   /id="PRO_0000370396"
FT   REPEAT          447..488
FT                   /note="WD 1"
FT   REPEAT          490..528
FT                   /note="WD 2"
FT   REPEAT          572..614
FT                   /note="WD 3"
FT   REPEAT          617..655
FT                   /note="WD 4"
FT   REPEAT          658..697
FT                   /note="WD 5"
FT   REPEAT          701..740
FT                   /note="WD 6"
FT   REPEAT          756..786
FT                   /note="WD 7"
FT   REGION          1..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..69
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..111
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..135
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..161
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   786 AA;  90422 MW;  E0D0917A1726CEBD CRC64;
     MAKKSAIKRK VKAPESINEQ ASVSEQSENE EDEDLLQAVK DPGEDTTDDE GIDQEYQSDT
     SDDLLFESDE EGNYLGRKEA SSGEDEQGEE DDNDDEEEED EDEEESGSSD DDAKDDQPSG
     SKATLSKTTG DSSNIAVAIP PRRDPSKPEY ENSDTSDEED IRNTVGNIPM HWYDEYKHIG
     YDWDAKKIIK PPKGDQIDDF LRKIEDPDFW RTVKDPQTGQ EVLLTDEDIA LIKRVNSARI
     PNPEHNEYEP WIEWFSSQVE KMPIKNVPDH KRSFLPSVSE KKKVSRMVHA LKMGWMKTTE
     EVERDKQQKR GPKFYMLWET DTGREHIRRI HDPVSAPKRD LPGHAESYNP PPEYLFDAKE
     MKEWLKYKDE PHKRKLHFMP QKFKSLREVP AYSRFLRERF LRCLDLYLCP RAKRVKLNID
     AEYLIPKLPS PRDLQPFPTV ESLVYRGHTD LVRSVSVEPK GEYIVSGSDD KTVKIWEIAT
     GRCIRTIETN DVVRCVAWCP NAKLSIIAVA TGTRLLLINP KVGDKLLVKK TDDLLAEAPS
     SDVIESERIK TAVQWSNAEP EEQEKGVRVV ITHFKPIRQV TWHGRGDYLA TVMPEGANRS
     ALIHQLSKRR SQIPFSKSKG LIQCVLFHPV KPCFFVATQH NIRIYDLVKQ ELIKKLLTNS
     KWISGMSIHP KGDNLLVSTY DKKMLWFDLD LSTKPYQTMR LHRNAVRSIA FHLRYPLFAS
     GSDDQAVIVS HGMVYNDLLQ NPLIVPLKKL QTHEKRDEFG VLDVNWHPVQ PWIFSTGADC
     TIRLYT