ID   BOP1_DROMO              Reviewed;         792 AA.
AC   B4KQU8;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN   ORFNames=GI19116;
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; CH933808; EDW09297.1; -; Genomic_DNA.
DR   RefSeq; XP_002005362.1; XM_002005326.2.
DR   AlphaFoldDB; B4KQU8; -.
DR   SMR; B4KQU8; -.
DR   STRING; 7230.FBpp0168333; -.
DR   PRIDE; B4KQU8; -.
DR   EnsemblMetazoa; FBtr0169841; FBpp0168333; FBgn0141855.
DR   GeneID; 6579466; -.
DR   KEGG; dmo:Dmoj_GI19116; -.
DR   eggNOG; KOG0650; Eukaryota.
DR   HOGENOM; CLU_011390_0_1_1; -.
DR   InParanoid; B4KQU8; -.
DR   OMA; MRPAKGE; -.
DR   OrthoDB; 759498at2759; -.
DR   PhylomeDB; B4KQU8; -.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0035206; P:regulation of hemocyte proliferation; IEA:EnsemblMetazoa.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..792
FT                   /note="Ribosome biogenesis protein BOP1 homolog"
FT                   /id="PRO_0000370398"
FT   REPEAT          453..494
FT                   /note="WD 1"
FT   REPEAT          496..534
FT                   /note="WD 2"
FT   REPEAT          578..620
FT                   /note="WD 3"
FT   REPEAT          623..661
FT                   /note="WD 4"
FT   REPEAT          664..703
FT                   /note="WD 5"
FT   REPEAT          707..746
FT                   /note="WD 6"
FT   REPEAT          762..792
FT                   /note="WD 7"
FT   REGION          1..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..69
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..117
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..138
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   792 AA;  91434 MW;  59680327DD01F82B CRC64;
     MTKKRTVKRK VKEPEPTKEQ PSVSEQSENE EDEDLLQAVK DPGEDTTDDE GIDQEYQSDS
     SEDLEFESDE EGNYLGRKVS NEAEEGEDDQ DEDDDEDEDE GEDEDDDSDD DSEESDANEA
     SATPKDDQPS SSKAAAAQTK EPIIQIIPRD PSKPEYEESD TSDEEDIRNT VGNIPMHWYD
     EYKHIGYDWD AKKIIKPPKG DQIDDFLRKI EDPNFWRTVK DPMTGQEVLL TDEDIALIKR
     VNSSRIPNPE HDEYAPWIEW FTSEVEKMPI KNVPDHKRSF LPSVSEKKKV SRMVHALKMG
     WMKTTEEVER EKQQKRGPKF YMLWETDTGR EHMRRIHDPV SAPKRDLPGH AESYNPPPEY
     LFDEKETKEW LKLKDEPHKR KLHFMPQKYK SLRAVPAYSR YLRERFLRCL DLYLCPRAKR
     VKLNIDAEYL IPKLPSPRDL QPFPTVESLV YRGHTDLVRS VSVEPKGEYL VSGSDDKTVK
     IWEIATGRCI RTIETNDVVR CVAWCPNAKL SIIAVATGSR LLLINPKVGD KLLIKKTDDL
     LAESPNLDII ESERIKTAVQ WSNAEPDEQE KGVRVVITHF KPIRQVTWHG RGDYLATVMP
     EGANRSALIH QLSKRRSQIP FSKSKGLIQC VLFHPVKPCF FVATQHNIRI YDLVKQELIK
     KLLTNSKWIS GMSIHPKGDN LLVSTYDKKM LWFDLDLSTK PYQTMRLHRN AVRSVAFHLR
     YPLFASGSDD QAVIVSHGMV YNDLLQNPLI VPLKKLQTHE KRDEFGVLDV TWHPVQPWVF
     STGADCTIRL YT