ID   BOP1_DROPE              Reviewed;         785 AA.
AC   B4GIU9;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN   ORFNames=GL17224;
OS   Drosophila persimilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7234;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSH-3 / Tucson 14011-0111.49;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; CH479183; EDW35434.1; -; Genomic_DNA.
DR   RefSeq; XP_002017595.1; XM_002017559.1.
DR   AlphaFoldDB; B4GIU9; -.
DR   SMR; B4GIU9; -.
DR   STRING; 7234.FBpp0181331; -.
DR   EnsemblMetazoa; FBtr0182839; FBpp0181331; FBgn0154827.
DR   GeneID; 6592244; -.
DR   KEGG; dpe:6592244; -.
DR   eggNOG; KOG0650; Eukaryota.
DR   HOGENOM; CLU_011390_1_0_1; -.
DR   OMA; MRPAKGE; -.
DR   PhylomeDB; B4GIU9; -.
DR   Proteomes; UP000008744; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0035206; P:regulation of hemocyte proliferation; IEA:EnsemblMetazoa.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..785
FT                   /note="Ribosome biogenesis protein BOP1 homolog"
FT                   /id="PRO_0000370399"
FT   REPEAT          446..487
FT                   /note="WD 1"
FT   REPEAT          489..527
FT                   /note="WD 2"
FT   REPEAT          571..613
FT                   /note="WD 3"
FT   REPEAT          616..654
FT                   /note="WD 4"
FT   REPEAT          657..696
FT                   /note="WD 5"
FT   REPEAT          700..739
FT                   /note="WD 6"
FT   REPEAT          755..785
FT                   /note="WD 7"
FT   REGION          1..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..39
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..70
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..86
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..101
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..121
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..160
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   785 AA;  90261 MW;  F385B6170F4A6482 CRC64;
     MTKKLTIKRK VKEPEPQNEA PDSHESSDNE EEEEDLLQAV KDPGEDSTDD EGIDQEYQTD
     SSEDLEFESD EEGNYLGRKG AEGSSGDDDE ESAEDEEEED DADAKKSSKN NDEEAATTSK
     SIKKSQEKPT SSNKVVPVVP ARDPSKVEYA DSDTSDEEDI RNTVGNIPMH WYDEYKHIGY
     DWDAKKIVKP PKGDQIDDFL RKIEDPNFWR TVKDPLTGQE VLLTDADIAL IKRINSGRIP
     NEEHDEYAPW IEWFTSEVEK MPIKNVPDHK RSFLPSGSEK KTVSRMVHAL KMGWMKTTEE
     VQREKQEKRG PKFYMLWETD TSREQMRRIH DPVSAPKRDL PGHAESYNPP PEYLFDEKEA
     KEWHKLKDEP HRRKLHFMPQ KFKSLREVPA YSRYLRERFL RCLDLYLCPR AKRVKLNIDA
     EYLIPKLPSP RDLQPFPTVE SLVYRGHTDL VRSVSVEPKG EYLVSGSDDK TVKIWEIATG
     RCIRTIETED VVRCVAWCPN AKLSIIAVAT GSRLLLVNPK VGDKLLVKKT DDLLAEAPVL
     DVIENERIKT AVQWANAEPA DQEKGVRVII THFKPIRQVT WHGRGDYLAT VMPEGANRSA
     LIHQLSKRRS QIPFSKSKGL IQCVLFHPVK PCFFVATQHN IRIYDLVKQE LIKKLLTNSK
     WISGMSIHPK GDNLLVSTYD KKMLWFDLDL STKPYQTMRL HRNAVRSVAF HLRYPLFASG
     SDDQAVIVSH GMVYNDLLQN PLIVPLKKLQ THEKREEFGV LDVNWHPVQP WVFSTGADCT
     IRLFT