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BOP1_DROPS
ID   BOP1_DROPS              Reviewed;         786 AA.
AC   Q28XF0;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN   ORFNames=GA18610;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; CM000071; EAL26366.1; -; Genomic_DNA.
DR   RefSeq; XP_001361787.1; XM_001361750.4.
DR   AlphaFoldDB; Q28XF0; -.
DR   SMR; Q28XF0; -.
DR   STRING; 7237.FBpp0278581; -.
DR   EnsemblMetazoa; FBtr0280143; FBpp0278581; FBgn0078611.
DR   GeneID; 4805377; -.
DR   KEGG; dpo:Dpse_GA18610; -.
DR   eggNOG; KOG0650; Eukaryota.
DR   HOGENOM; CLU_011390_2_0_1; -.
DR   InParanoid; Q28XF0; -.
DR   OMA; MRPAKGE; -.
DR   PhylomeDB; Q28XF0; -.
DR   Proteomes; UP000001819; Chromosome 3.
DR   Bgee; FBgn0078611; Expressed in female reproductive system and 3 other tissues.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0035206; P:regulation of hemocyte proliferation; IEA:EnsemblMetazoa.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..786
FT                   /note="Ribosome biogenesis protein BOP1 homolog"
FT                   /id="PRO_0000370400"
FT   REPEAT          447..488
FT                   /note="WD 1"
FT   REPEAT          490..528
FT                   /note="WD 2"
FT   REPEAT          572..614
FT                   /note="WD 3"
FT   REPEAT          617..655
FT                   /note="WD 4"
FT   REPEAT          658..697
FT                   /note="WD 5"
FT   REPEAT          701..740
FT                   /note="WD 6"
FT   REPEAT          756..786
FT                   /note="WD 7"
FT   REGION          1..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..40
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..71
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..87
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..102
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        103..122
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        147..161
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   786 AA;  90390 MW;  12618254F8A7972C CRC64;
     MTKKLTIKRK VKEPEPQNEA PDSHESSDNE EEEEEDLLQA VKDPGEDSTD DEGIDQEYQT
     DSSEDLEFES DEEGNYLGRK GAEGSSGDDD EESAEDEEEE DDADAKKSSK NNDEEAATTS
     KSIKKSQEKP TSSNKVVPVV PARDPSKVEY ADSDTSDEED IRNTVGNIPM HWYDEYKHIG
     YDWDAKKIVK PPKGDQIDDF LRKIEDPNFW RTVKDPLTGQ EVLLTDADIA LIKRINSGRI
     PNEEHDEYAP WIEWFTSEVE KMPIKNVPDH KRSFLPSGSE KKTVSRMVHA LKMGWMKTTE
     EVQREKQEKR GPKFYMLWET DTSREQMRRI HDPVSAPKRD LPGHAESYNP PPEYLFDEKE
     AKEWHKLKDE PHRRKLHFMP QKFKSLREVP AYSRYLRERF LRCLDLYLCP RAKRVKLNID
     AEYLIPKLPS PRDLQPFPTV ESLVYRGHTD LVRSVSVEPK GEYLVSGSDD KTVKIWEIAT
     GRCIRTIETE DVVRCVAWCP NAKLSIIAVA TGSRLLLVNP KVGDKLLVKK TDDLLAEAPV
     LDVIENERIK TAVQWANAEP ADQEKGVRVI ITHFKPIRQV TWHGRGDYLA TVMPEGANRS
     ALIHQLSKRR SQIPFSKSKG LIQCVLFHPV KPCFFVATQH NIRIYDLVKQ ELIKKLLTNS
     KWISGMSIHP KGDNLLVSTY DKKMLWFDLD LSTKPYQTMR LHRNAVRSVA FHLRYPLFAS
     GSDDQAVIVS HGMVYNDLLQ NPLIVPLKKL QTHEKREEFG VLDVNWHPVQ PWVFSTGADC
     TIRLFT
 
 
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