ID   BOP1_DROSE              Reviewed;         784 AA.
AC   B4HN85;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN   ORFNames=GM21825;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; CH480816; EDW48367.1; -; Genomic_DNA.
DR   RefSeq; XP_002034354.1; XM_002034318.1.
DR   AlphaFoldDB; B4HN85; -.
DR   SMR; B4HN85; -.
DR   STRING; 7238.B4HN85; -.
DR   PRIDE; B4HN85; -.
DR   EnsemblMetazoa; FBtr0204810; FBpp0203302; FBgn0176702.
DR   GeneID; 6609697; -.
DR   KEGG; dse:6609697; -.
DR   HOGENOM; CLU_011390_2_0_1; -.
DR   OMA; MRPAKGE; -.
DR   PhylomeDB; B4HN85; -.
DR   Proteomes; UP000001292; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0035206; P:regulation of hemocyte proliferation; IEA:EnsemblMetazoa.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..784
FT                   /note="Ribosome biogenesis protein BOP1 homolog"
FT                   /id="PRO_0000370401"
FT   REPEAT          445..486
FT                   /note="WD 1"
FT   REPEAT          488..526
FT                   /note="WD 2"
FT   REPEAT          570..612
FT                   /note="WD 3"
FT   REPEAT          615..653
FT                   /note="WD 4"
FT   REPEAT          656..695
FT                   /note="WD 5"
FT   REPEAT          699..738
FT                   /note="WD 6"
FT   REPEAT          754..784
FT                   /note="WD 7"
FT   REGION          1..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..39
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..85
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..109
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..159
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   784 AA;  90457 MW;  E59CF21E8AE5522B CRC64;
     MTKKLALKRR GKDSEPTNEV VASSEASENE EEEEDLLQAV KDPGEDSTDD EGIDQEYHSD
     SSEELQFESD EEGNYLGRKQ SSSAEEDEES SDEEDNEEEG STDEEEVEDE EKVSKSKQSD
     DKPSGSGAAS KKALTAELPK RDSSKPEYQD SDTSDEEDIR NTVGNIPMHW YDEYKHIGYD
     WDAKKIIKPP QGDQIDEFLR KIEDPDFWRT VKDPLTGQDV RLTDEDIALI KRIVSGRIPN
     KDHEEYEPWI EWFTSEVEKM PIKNVPDHKR SFLPSVSEKK RVSRMVHALK MGWMKTTEEV
     EREKQAKRGP KFYMLWETDT SREHMRRIHD PVSAPKRDLP GHAESYNPPP EYLFDAKETK
     EWLKLKDEPH KRKLHFMPQK FKSLREVPAY SRYLRERFLR CLDLYLCPRA KRVKLNIDAE
     YLIPKLPSPR DLQPFPTVES MVYRGHTDLV RSVSVEPKGE YLVSGSDDKT VKIWEIATGR
     CIRTIETDEV VRCVAWCPNP KLSIIAVATG NRLLLVNPKV GDKVLVQKTD DLLAEAPSQD
     VIESERIKTA VQWSNAEADE QEKGVRVVIT HFKPIRQVTW HGRGDYLATV MPEGANRSAL
     IHQLSKRRSQ IPFSKSKGLI QFVLFHPVKP CFFVATQHNI RIYDLVKQEL VKKLLTNSKW
     ISGMSIHPKG DNLLVSTYDK KMLWFDLDLS TKPYQTMRLH RNAVRSVAFH RRYPLFASGS
     DDQAVIVSHG MVYNDLLQNP LIVPLKKLQT HEKRDEFGVL DVNWHPVQPW VFSTGADSTI
     RLYT