ID   BOP1_DROVI              Reviewed;         780 AA.
AC   B4LKS9;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN   ORFNames=GJ22246;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; CH940648; EDW61802.1; -; Genomic_DNA.
DR   RefSeq; XP_002050609.1; XM_002050573.2.
DR   AlphaFoldDB; B4LKS9; -.
DR   SMR; B4LKS9; -.
DR   STRING; 7244.FBpp0236663; -.
DR   EnsemblMetazoa; FBtr0238171; FBpp0236663; FBgn0209359.
DR   GeneID; 6624813; -.
DR   KEGG; dvi:6624813; -.
DR   eggNOG; KOG0650; Eukaryota.
DR   HOGENOM; CLU_011390_2_0_1; -.
DR   InParanoid; B4LKS9; -.
DR   OMA; MRPAKGE; -.
DR   OrthoDB; 759498at2759; -.
DR   PhylomeDB; B4LKS9; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0035206; P:regulation of hemocyte proliferation; IEA:EnsemblMetazoa.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..780
FT                   /note="Ribosome biogenesis protein BOP1 homolog"
FT                   /id="PRO_0000370402"
FT   REPEAT          441..482
FT                   /note="WD 1"
FT   REPEAT          484..522
FT                   /note="WD 2"
FT   REPEAT          566..608
FT                   /note="WD 3"
FT   REPEAT          611..649
FT                   /note="WD 4"
FT   REPEAT          652..691
FT                   /note="WD 5"
FT   REPEAT          695..734
FT                   /note="WD 6"
FT   REPEAT          750..780
FT                   /note="WD 7"
FT   REGION          1..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..69
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..113
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   780 AA;  89899 MW;  034CF701616BDD60 CRC64;
     MTKKQAIKRK VKEPEPTNEQ SSASEPSDNE EDDDLLQAVK DPGEDTTDDE GIDQEYQSDS
     SEDLEFESDE EGNYLGRKAN NEAEGDAEED EDDDEEEDED SDEASEDNDD AEEEKPSSSM
     TAAVQTKVEP IIQIIPRDPS KPEYEDSDTS DEEDIRNTVG NIPMHWYDEY KHIGYDWDAK
     KIVKPPKGDQ IDDFLRKIED PNFWRTVKDP QTGQEVLLTD EDIALIKRVN SGRIPNAEHD
     EYAPWIEWFT SEVEKMPIKN VPDHKRSFLP SVSEKKKVSR MVHALKMGWM KTTEEVEREK
     QKKRGPKFYM LWETDTGRES MRRIHDPVSA PKRDLPGHAE SYNPPPEYLF DEKETKEWLK
     QKDEPHKRKL HFMPQKFKSL REVPAYSRYL RERFLRCLDL YLCPRAKRVK LNIDAEYLIP
     KLPSPRDLQP FPTVESLVYR GHTDLVRSVS VEPKGEYMAS GSDDKTVKIW EIATGRCIRT
     IETNDVVRCV AWCPNAKLSI IAVATGSRLL LINPKVGDKL LIKKTDDLLA ASPSLDVIDN
     ERIKTAVQWS NAEPEEQEKG VRVVITHFKP IRQVTWHGRG DYLATVMPEG ANRSALIHQL
     SKRRSQIPFS KSKGLIQCVL FHPVKPCFFV ATQHNIRIYD LVKQELIKKL LTNSKWISGM
     SIHPKGDNLL VSTYDKKMLW FDLDLSTKPY QTMRLHRNAV RSVAFHLRYP LFASGSDDQA
     VIVSHGMVYN DLLQNPLIVP LKKLQTHEKR DEFGVLDVSW HPVQPWVFST GADCTIRLYT