ID   BOP1_DROWI              Reviewed;         778 AA.
AC   B4MYI5;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN   ORFNames=GK22227;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; CH963894; EDW77174.1; -; Genomic_DNA.
DR   RefSeq; XP_002066188.1; XM_002066152.2.
DR   AlphaFoldDB; B4MYI5; -.
DR   SMR; B4MYI5; -.
DR   STRING; 7260.FBpp0251370; -.
DR   PRIDE; B4MYI5; -.
DR   EnsemblMetazoa; FBtr0252878; FBpp0251370; FBgn0224212.
DR   GeneID; 6643324; -.
DR   KEGG; dwi:6643324; -.
DR   eggNOG; KOG0650; Eukaryota.
DR   HOGENOM; CLU_011390_1_0_1; -.
DR   InParanoid; B4MYI5; -.
DR   OMA; MRPAKGE; -.
DR   OrthoDB; 759498at2759; -.
DR   PhylomeDB; B4MYI5; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0035206; P:regulation of hemocyte proliferation; IEA:EnsemblMetazoa.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..778
FT                   /note="Ribosome biogenesis protein BOP1 homolog"
FT                   /id="PRO_0000370403"
FT   REPEAT          438..479
FT                   /note="WD 1"
FT   REPEAT          481..519
FT                   /note="WD 2"
FT   REPEAT          564..606
FT                   /note="WD 3"
FT   REPEAT          609..647
FT                   /note="WD 4"
FT   REPEAT          650..689
FT                   /note="WD 5"
FT   REPEAT          693..732
FT                   /note="WD 6"
FT   REPEAT          748..778
FT                   /note="WD 7"
FT   REGION          1..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..69
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..107
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   778 AA;  89722 MW;  380AA72D03289D30 CRC64;
     MAKKQDRKRK VKDEATNDGA SGSDQSDNAE EEEDLLQTVK EPGEDSTDDE GIDQEYQSDS
     SEDLEFESDE EGNYVGRKGG QQESSDEEEV DEEEEDDDDD DDEEEGGKVE DKPTTSSKAE
     TNNEVAPLPA LPARDPSKQE YEDSDTSDEE DIRNTVGNIP MHWYDEYKHI GYDWDGNKII
     KPIKGDQIDD FLRKIEDPDF WRTVKDPQTG QEVVLSDADI ALIKRINSAR IPNAEHEEYE
     PWIEWFTSEV EKMPIKNVPD HKRSFLPSVS EKKRVSRMVH ALKMGWMKTT EEVEREKQQK
     RGPKFYMLWE TDTGREQMRR IHDPVSAPKR DLPGHAESYN PPPEYLFDEK ETKQWLKLKD
     EPHKRKLHFM PQKFKSLREV PAYSRYLRER FLRCLDLYLC PRAKRVKLNI DAEYLIPKLP
     SPRDLQPFPT VESLVYRGHT DLVRSVSVEP KGEYMVSGSD DKTVKIWEIA TGRCIRTIET
     EDVVRCVAWC PNAKLSIIAV ATGSRLLLVN PKVGDKLLIK KTDDLLAEEP SNQDIIDNER
     IKTAVQWSTA EAAEQEKGVR VIINHFKPIR QVTWHGRGDY LATVMPEGAN RSALIHQLSK
     RRSQIPFSKS KGLIQCVLFH PVKPCFFVAT QHNIRIYDLV KQELIKKLLT NSKWISGMSI
     HPKGDNLLVS TYDKKMLWFD LDLSTKPYQT MRLHRNAVRS VAFHLRYPLF ASGSDDQAVI
     VSHGMVYNDL LQNPLIVPLK KLQTHEKRDD FGVLDVCWHP VQPWVFSTGA DCTIRLYT