ID   BOP1_LEIBR              Reviewed;         743 AA.
AC   A4H6F7;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN   ORFNames=LbrM11_V2.0090, LbrM_11_0090;
OS   Leishmania braziliensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC   Leishmania braziliensis species complex.
OX   NCBI_TaxID=5660;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904;
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Sqaures R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; FR798985; CAM41909.1; -; Genomic_DNA.
DR   RefSeq; XP_001562944.1; XM_001562894.1.
DR   AlphaFoldDB; A4H6F7; -.
DR   SMR; A4H6F7; -.
DR   STRING; 5660.A4H6F7; -.
DR   PRIDE; A4H6F7; -.
DR   GeneID; 5413433; -.
DR   KEGG; lbz:LBRM_11_0090; -.
DR   VEuPathDB; TriTrypDB:LbrM.11.0090; -.
DR   VEuPathDB; TriTrypDB:LBRM2903_110005800; -.
DR   InParanoid; A4H6F7; -.
DR   OMA; MRPAKGE; -.
DR   Proteomes; UP000007258; Chromosome 11.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..743
FT                   /note="Ribosome biogenesis protein BOP1 homolog"
FT                   /id="PRO_0000370410"
FT   REPEAT          365..404
FT                   /note="WD 1"
FT   REPEAT          575..615
FT                   /note="WD 2"
FT   REPEAT          617..655
FT                   /note="WD 3"
FT   REPEAT          659..701
FT                   /note="WD 4"
FT   REPEAT          712..743
FT                   /note="WD 5"
SQ   SEQUENCE   743 AA;  84316 MW;  87B456E3812DEF81 CRC64;
     MLPGYTAESK DGAHGYERLH DIILQDSDAD GEDDVILFPH AEELANAAVG IDGDDGNGRV
     VRLGTTQHLD ESDSSEDEAT LNRVGDIPLE WYKDEKHIGY DIEGKKLMKA ERSALERLLE
     ATDDPNAMRT IYDALHDEKK TLSNADLQLI FNLQRNRTTN SNYDMYSGVQ EDTVVFDPLN
     HPLARSSGPS KKAFVPALHD TKVIAKMVRR LRKEEAESKL RPATEEKEDE DQLLWDDGHV
     EMDTHTHFKY FNRVPKPKVP PPGTFESYRP PPEYLPSERA KQRQARLRTI DRREHFLPQS
     FDALRHVPFY HHTIQDRYQR CLDLAFFPRA QRTRLVVDPD KLLPELPNPK DLRPYPEKLS
     FHYKGHTATV RSVSVSPNGQ YLATGCDDHL VRVYEVQTGR LMKRYDMGAP VQQVEFCPSK
     SLNILAAAVE YSLVFVVPTF AAHALVNDHT IRFLRAPGLS AGQREAAHAL GAVDTLGGRA
     VTQTTLDADE TAHEATTDLH DVEEREKRAE FLDASAKERN AGIVVKIAMH AKVKKFCFHI
     KGDYLCALCP KDHVKYRQTI MLQLSKRKVF CPFRKFSEVV TDCRFHPREP LFFLATTNSV
     RCYNLMAHRL QRRFKASGGV TTCLSIHPEG DNFLVGDTTS HTSWFDMDFS DKPYKRMRSH
     KGVVNALAFH PKTGAYPLFA TGASDGQVHV FHGMVYDDYN KNALVVPVKI LKHQRSVYAV
     AWHPSLAWLF TSTEDGVVTA WTE